SCHEMBL2268019

SCHEMBL2268019

Cc1ccccc1C(=O)Nc1cc(Oc2ccccc2)ccc1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.57
GFER P55789 1/20 0.57
LMNA P02545 1/20 0.56
NR1H4 Q96RI1 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
ALDH1A1 P00352 4/20 0.54
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
POLB P06746 2/20 0.50
GAA P10253 2/20 0.50
KDM4E B2RXH2 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
CRHBP P24387 1/20 0.50
FNTA P49354 1/20 0.50
FNTB P49356 1/20 0.50
CRHR2 Q13324 1/20 0.50
HPGD P15428 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2271352 0.91 MAPK1 (0.57) MAPK1GFERLMNANR1H4CYP2C9
SCHEMBL2289345 0.90 MAPK1 (0.57) MAPK1GFERNR1H4MEN1KMT2A
SCHEMBL2274195 0.85 PNLIP (0.66) MAPK1GFERLMNAMEN1KMT2A
SCHEMBL2270154 0.85 KMT2A (0.65) MAPK1LMNACYP2C9CYP2C19MEN1
SCHEMBL2269563 0.84 STK39 (0.57) MAPK1GFERCYP2C9CYP2C19ALDH1A1
SCHEMBL2275036 0.84 L3MBTL1 (0.64) MAPK1GFERLMNACYP2C9CYP2C19
SCHEMBL2273533 0.84 TDP1 (0.69) LMNANR1H4CYP2C9CYP2C19MEN1
SCHEMBL2271588 0.83 SERPINE1 (0.64) NR1H4MEN1KMT2APOLBNPC1
SCHEMBL2272800 0.83 HTT (0.52) MAPK1GFERMEN1KMT2AL3MBTL1
SCHEMBL2275467 0.83 CYP2C9 (0.63) MAPK1GFERNR1H4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MAPK1 168/4885GFER 823/4885LMNA 3235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.