SCHEMBL2270231

SCHEMBL2270231

O=C(Nc1cc(Oc2ccc3c(c2)OCO3)ccc1C(=O)O)c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 1/20 0.59
SENP8 Q96LD8 1/20 0.59
SENP7 Q9BQF6 1/20 0.59
SENP6 Q9GZR1 1/20 0.59
NPC1 O15118 5/20 0.57
RAB9A P51151 5/20 0.57
PYGM P11217 3/20 0.56
PYGL P06737 2/20 0.56
PTGS2 P35354 1/20 0.55
MAPT P10636 2/20 0.53
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
PKM P14618 3/20 0.51
TDP1 Q9NUW8 2/20 0.51
GRIK1 P39086 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
HPSE Q9Y251 1/20 0.50
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2271438 0.93 NPC1 (0.57) CASP3SENP8SENP7SENP6NPC1
SCHEMBL2267865 0.91 CASP3 (0.73) CASP3SENP8SENP7SENP6NPC1
SCHEMBL2274795 0.85 NPC1 (0.60) NPC1RAB9APTGS2MAPTMEN1
SCHEMBL2271588 0.85 SERPINE1 (0.64) NPC1RAB9APYGMPYGLMAPT
SCHEMBL2276607 0.84 CASP3 (0.63) CASP3SENP8SENP7SENP6NPC1
SCHEMBL2276071 0.82 CA12 (0.58) NPC1RAB9APTGS2MAPTMEN1
SCHEMBL2276083 0.82 CA12 (0.58) NPC1RAB9APTGS2MAPTMEN1
SCHEMBL2274898 0.81 SERPINE1 (0.60) NPC1RAB9APYGMPYGLMAPT
SCHEMBL7128825 0.81 PYGM (0.66) CASP3SENP8SENP7SENP6NPC1
SCHEMBL1656724 0.80 ALDH1A1 (0.57) CASP3SENP8SENP7SENP6NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 CASP3 139/4885SENP8 2469/4885SENP7 2305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.