SCHEMBL2276607

SCHEMBL2276607

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1ccc2c(c1)OCCO2

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 1/20 0.63
SENP8 Q96LD8 1/20 0.63
SENP7 Q9BQF6 1/20 0.63
SENP6 Q9GZR1 1/20 0.63
KMT2A Q03164 5/20 0.58
SMN1; SMN2 Q16637 3/20 0.58
MEN1 O00255 3/20 0.58
POLB P06746 2/20 0.58
KDM4E B2RXH2 1/20 0.58
ALDH1A1 P00352 1/20 0.58
TP53 P04637 1/20 0.58
MAPT P10636 1/20 0.58
NPC1 O15118 7/20 0.58
RAB9A P51151 7/20 0.58
PKM P14618 2/20 0.58
NFKB1 P19838 1/20 0.58
MAOB P27338 1/20 0.58
NFKB2 Q00653 1/20 0.58
RELA Q04206 1/20 0.58
TDP1 Q9NUW8 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2267865 0.93 CASP3 (0.73) CASP3SENP8SENP7SENP6KMT2A
SCHEMBL2271438 0.91 NPC1 (0.57) CASP3SENP8SENP7SENP6KMT2A
SCHEMBL5145182 0.84 NPC1 (0.61) KMT2ASMN1; SMN2MEN1POLBKDM4E
SCHEMBL2270231 0.84 CASP3 (0.59) CASP3SENP8SENP7SENP6KMT2A
SCHEMBL2271588 0.83 SERPINE1 (0.64) KMT2AMEN1POLBMAPTNPC1
SCHEMBL2276915 0.81 RAB9A (0.61) KMT2ASMN1; SMN2MEN1POLBKDM4E
SCHEMBL2270621 0.81 GALK1 (0.68) NPC1RAB9ATDP1SERPINE1HPSE
SCHEMBL2276745 0.81 SERPINE1 (0.65) KMT2ASMN1; SMN2MEN1MAPTNPC1
SCHEMBL2272774 0.80 KMT2A (0.63) KMT2ASMN1; SMN2MEN1POLBNPC1
SCHEMBL2273533 0.80 TDP1 (0.69) KMT2AMEN1MAPTRAB9ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 CASP3 139/4885SENP8 2469/4885SENP7 2305/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.