SCHEMBL2276254

SCHEMBL2276254

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1ccc(F)c(F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA4 P22748 1/20 0.48
CA7 P43166 1/20 0.48
PLK1 P53350 6/20 0.48
PLK3 Q9H4B4 4/20 0.48
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
PKM P14618 2/20 0.47
LTC4S Q16873 1/20 0.46
HDAC1 Q13547 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
MAPT P10636 2/20 0.46
GRIK1 P39086 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
MCL1 Q07820 1/20 0.46
BCL2A1 Q16548 1/20 0.46
PRSS12 P56730 1/20 0.45
RXFP1 Q9HBX9 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2271933 0.88 MEN1 (0.54) PLK1PLK3MEN1KMT2APKM
SCHEMBL2275929 0.86 KMT2A (0.62) CA12CA1CA4CA7PLK1
SCHEMBL2275745 0.85 NPC1 (0.56) MEN1KMT2APKMLTC4SMAPT
SCHEMBL2274700 0.85 MEN1 (0.55) PLK1PLK3MEN1KMT2APKM
SCHEMBL2270587 0.85 LTC4S (0.48) CA12CA1CA4CA7PLK1
SCHEMBL2271080 0.84 MEN1 (0.56) PLK1PLK3MEN1KMT2APKM
SCHEMBL2270925 0.84 PLK1 (0.57) CA12CA1CA4CA7PLK1
SCHEMBL2271421 0.84 DHODH (0.63) PLK1PLK3MEN1KMT2APKM
SCHEMBL2276434 0.84 RAB9A (0.55) MEN1KMT2AGRIK1TDP1
SCHEMBL2270906 0.83 MEN1 (0.56) CA12CA1CA4CA7PLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 CA12 31/4885CA1 26/4885CA4 23/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.