SCHEMBL2270968

SCHEMBL2270968

CC(C)(C)OC(=O)c1ccc(CCc2ccccc2)cc1NS(=O)(=O)Cc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ACLY P53396 5/20 0.51
ALDH1A1 P00352 4/20 0.43
MAPK1 P28482 1/20 0.43
PTK2B Q14289 1/20 0.43
STS P08842 1/20 0.42
HPGD P15428 3/20 0.41
F2 P00734 1/20 0.41
KDM4E B2RXH2 3/20 0.40
HSD17B10 Q99714 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276451 0.83 ACLY (0.71) ACLYALDH1A1HPGDKDM4EHSD17B10
SCHEMBL4220608 0.81 ADRA1A (0.46) ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL4221441 0.77 SIRT2 (0.46) ACLYMAPT
SCHEMBL4217327 0.77 RAB9A (0.42) KDM4E
SCHEMBL14213080 0.76 FFAR4 (0.43) HPGD
SCHEMBL4222218 0.76 P2RX7 (0.46) MAPK1
SCHEMBL4215772 0.76 SIRT2 (0.45) ALDH1A1KDM4EMAPT
SCHEMBL2275189 0.76 MAPK1 (0.54) ALDH1A1MAPK1HPGDKDM4EHSD17B10
SCHEMBL4210622 0.76 AKR1C3 (0.48) ALDH1A1MAPT
SCHEMBL4219791 0.76 ADRA1A (0.39) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ACLY 653/4885ALDH1A1 645/4885MAPK1 168/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.