SCHEMBL2273288

SCHEMBL2273288

O=C(O)c1ccc(CCc2ccccc2)cc1NC(=O)c1ccc(C(F)(F)F)cc1C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 1/20 0.49
GPR27 Q9NS67 1/20 0.49
PLK1 P53350 1/20 0.48
GRIK1 P39086 2/20 0.47
RXFP1 Q9HBX9 4/20 0.47
PPARG P37231 2/20 0.46
PPARD Q03181 2/20 0.46
PPARA Q07869 2/20 0.46
NR1H4 Q96RI1 2/20 0.46
MPO P05164 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
CES2 O00748 1/20 0.45
ACLY P53396 2/20 0.44
SORT1 Q99523 2/20 0.44
ESRRG P62508 1/20 0.43
TAS2R14 Q9NYV8 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276347 0.90 MEN1 (0.56) GRIK1RXFP1PPARGPPARDPPARA
SCHEMBL2269100 0.87 PLK1 (0.56) PLK1PPARGPPARDPPARANR1H4
SCHEMBL2274939 0.86 PLK1 (0.55) PLK1GRIK1RXFP1PPARGPPARD
SCHEMBL2270805 0.84 LMNA (0.56) PLK1GRIK1RXFP1PPARGPPARD
SCHEMBL2270705 0.84 ACLY (0.59) PLK1GRIK1RXFP1PPARGPPARD
SCHEMBL2274023 0.82 ACLY (0.64) AVPR2GPR27GRIK1RXFP1MPO
SCHEMBL2275929 0.80 KMT2A (0.62) PLK1GRIK1MEN1KMT2AACLY
SCHEMBL2274737 0.80 AVPR2 (0.49) AVPR2GPR27GRIK1RXFP1PPARG
SCHEMBL4220677 0.79 MEN1 (0.56) GRIK1MPOMEN1KMT2AACLY
SCHEMBL2276434 0.78 RAB9A (0.55) GRIK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 AVPR2 1644/4885GPR27 2347/4885PLK1 4227/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.