SCHEMBL2276347

SCHEMBL2276347

O=C(O)c1ccc(CCc2ccccc2)cc1NC(=O)c1ccccc1C(F)(F)F

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
GRIK1 P39086 1/20 0.49
KCNK3 O14649 1/20 0.49
KCNK9 Q9NPC2 1/20 0.49
RXFP1 Q9HBX9 3/20 0.48
POLB P06746 2/20 0.48
GAA P10253 2/20 0.48
LMNA P02545 1/20 0.47
PTGS1 P23219 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
F2R P25116 1/20 0.45
SLC1A3 P43003 1/20 0.44
SLC1A2 P43004 1/20 0.44
SLC1A1 P43005 1/20 0.44
TAS2R14 Q9NYV8 2/20 0.44
PTPRC P08575 1/20 0.44
RECQL P46063 1/20 0.44
BLM P54132 1/20 0.44
TDP1 Q9NUW8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2273288 0.90 AVPR2 (0.49) MEN1KMT2AGRIK1RXFP1TAS2R14
SCHEMBL2276434 0.84 RAB9A (0.55) MEN1KMT2AGRIK1POLBGAA
SCHEMBL2269100 0.83 PLK1 (0.56) KMT2APTGS1PPARGPPARDPPARA
SCHEMBL4211136 0.82 AKR1C3 (0.54) MEN1KMT2AGRIK1POLBGAA
SCHEMBL2270880 0.82 ALOX15 (0.60) MEN1KMT2AGAALMNARECQL
SCHEMBL2270705 0.82 ACLY (0.59) MEN1KMT2AGRIK1RXFP1TDP1
SCHEMBL2274939 0.81 PLK1 (0.55) MEN1KMT2AGRIK1RXFP1TDP1
SCHEMBL2276177 0.81 SLC16A3 (0.55) POLBGAASMN1; SMN2RECQL
SCHEMBL2274690 0.81 ACLY (0.61) MEN1KMT2AGRIK1KCNK3KCNK9
SCHEMBL2275852 0.81 MEN1 (0.55) MEN1KMT2AGRIK1POLBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 MEN1 3105/4885KMT2A 1669/4885GRIK1 2029/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.