SCHEMBL22749405

SCHEMBL22749405

O=C(ON1C(=O)CCC1=O)c1ccc(-n2cc(CN(Cc3ccccc3)Cc3ccccc3)nn2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 3/20 0.46
▸ POLB P06746 1/20 0.46
▸ APP P05067 2/20 0.45
▸ HSP90AB1 P08238 1/20 0.43
▸ MIF P14174 2/20 0.42
▸ MAOA P21397 1/20 0.42
▸ MAOB P27338 1/20 0.42
▸ CD74 P04233 1/20 0.42
▸ SLC6A9 P48067 1/20 0.41
▸ NPC1 O15118 2/20 0.40
▸ SMN1; SMN2 Q16637 2/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ CA12 O43570 2/20 0.39
▸ CA9 Q16790 2/20 0.39
▸ NOTUM Q6P988 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.38
▸ HSP90AA1 P07900 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ HTT P42858 1/20 0.38
▸ CA1 P00915 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22749452 0.82 MAOA (0.61) L3MBTL1POLBAPPHSP90AB1MIF
SCHEMBL29979916 0.80 MAOA (0.52) L3MBTL1POLBAPPHSP90AB1MIF
SCHEMBL22749404 0.74 NR3C1 (0.44) SMN1; SMN2ALDH1A1HSP90AA1MAPTHTT
SCHEMBL23567172 0.73 ESRRA (0.48) L3MBTL1POLBAPPMAOANPC1
SCHEMBL10041303 0.72 LMNA (0.47) L3MBTL1SMN1; SMN2RAB9AALDH1A1
SCHEMBL19309377 0.70 KMT2A (0.53) POLBNPC1SMN1; SMN2RAB9AALDH1A1
SCHEMBL133554 0.70 KMT2A (0.53) POLBNPC1SMN1; SMN2RAB9AALDH1A1
SCHEMBL300884 0.69 CA12 (0.42) SMN1; SMN2RAB9ACA12CA9ALDH1A1
SCHEMBL862827 0.68 NR4A1 (0.57) POLBMAOBNPC1RAB9AALDH1A1
SCHEMBL76714 0.68 KMT2A (0.48) L3MBTL1NPC1SMN1; SMN2RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12625144-B2 Chemoselective sensitivity booster for tagging a peptide, peptide conjugate, or similar reactive molecule Indian Institute Of Science Education And Research Bhopal (IN) 2026-05-12 — — US claimed
US-20220299521-A1 CHEMOSELECTIVE SENSITIVITY BOOSTER FOR TAGGING A PEPTIDE, PEPTIDE CONJUGATE, OR SIMILAR REACTIVE MOLECULE Indian Institute Of Science Education And Research Bhopal (IN) 2022-09-22 — — US claimed
US-12625144-B2 Chemoselective sensitivity booster for tagging a peptide, peptide conjugate, or similar reactive molecule Indian Institute Of Science Education And Research Bhopal (IN) 2026-05-12 — — US disclosed
US-20220299521-A1 CHEMOSELECTIVE SENSITIVITY BOOSTER FOR TAGGING A PEPTIDE, PEPTIDE CONJUGATE, OR SIMILAR REACTIVE MOLECULE Indian Institute Of Science Education And Research Bhopal (IN) 2022-09-22 — — US disclosed
WO-2020245843-A1 CHEMOSELECTIVE SENSITIVITY BOOSTER FOR TAGGING A PEPTIDE, PEPTIDE CONJUGATE, OR SIMILAR REACTIVE MOLECULE Indian Institute Of Science Education And Research Bhopal (IN) 2020-12-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220299521-A1 CHEMOSELECTIVE SENSITIVITY BOOSTER FOR TAGGING A PEPTIDE, PEPTIDE CONJUGATE, OR SIMILAR REACTIVE MOLECULE PTMS, PA2G4, MAX L3MBTL1 3442/4885POLB 4287/4885APP 689/4885
US-12625144-B2 Chemoselective sensitivity booster for tagging a peptide, peptide conjugate, or similar reactive molecule DPYSL3, CD2BP2, PTMS L3MBTL1 2740/4885POLB 3384/4885APP 1611/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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