SCHEMBL2274965

SCHEMBL2274965

O=C(O)c1ccc(Oc2ccccc2)cc1NC(=O)c1c(F)cccc1F

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.49
TDP1 Q9NUW8 1/20 0.49
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
SERPINE1 P05121 1/20 0.48
TLR8 Q9NR97 2/20 0.47
TLR7 Q9NYK1 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
MAPK1 P28482 1/20 0.47
GFER P55789 1/20 0.47
HPSE Q9Y251 1/20 0.47
RAB9A P51151 1/20 0.47
BRPF1 P55201 1/20 0.47
LMNA P02545 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275036 0.88 L3MBTL1 (0.64) L3MBTL1TDP1CYP2C9CYP2C19SERPINE1
SCHEMBL2274830 0.85 MEN1 (0.54) SERPINE1MEN1KMT2AHPSERAB9A
SCHEMBL2275857 0.85 SERPINE1 (0.54) CYP2C9CYP2C19SERPINE1TLR8TLR7
SCHEMBL2276447 0.85 SERPINE1 (0.54) TDP1CYP2C9CYP2C19SERPINE1HPSE
SCHEMBL2267950 0.84 NPC1 (0.56) L3MBTL1TDP1CYP2C9CYP2C19SERPINE1
SCHEMBL2267915 0.82 SERPINE1 (0.58) SERPINE1MEN1KMT2AHPSENPSR1
SCHEMBL2271588 0.82 SERPINE1 (0.64) TDP1SERPINE1MEN1KMT2AHPSE
SCHEMBL2273634 0.82 SERPINE1 (0.60) L3MBTL1TDP1SERPINE1MEN1KMT2A
SCHEMBL7120759 0.81 PYGL (0.66) L3MBTL1TDP1
SCHEMBL2269555 0.81 HPSE (0.55) TDP1SERPINE1MEN1KMT2AHPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 L3MBTL1 3822/4885TDP1 3823/4885CYP2C9 841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.