SCHEMBL2276447

SCHEMBL2276447

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1cc(F)cc(F)c1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SERPINE1 P05121 1/20 0.54
HPSE Q9Y251 1/20 0.50
PYGL P06737 1/20 0.50
PYGM P11217 1/20 0.50
PRSS12 P56730 1/20 0.48
GALK1 P51570 1/20 0.48
CASP6 P55212 1/20 0.48
MCL1 Q07820 1/20 0.48
PLEC Q15149 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
NR1H4 Q96RI1 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274830 0.90 MEN1 (0.54) SERPINE1HPSEPYGLPYGM
SCHEMBL2271524 0.90 PYGM (0.56) SERPINE1HPSEPYGLPYGMGALK1
SCHEMBL2273634 0.90 SERPINE1 (0.60) SERPINE1HPSEPYGLPYGMGALK1
SCHEMBL2274811 0.88 PYGM (0.57) SERPINE1HPSEPYGLPYGMGALK1
SCHEMBL2271588 0.88 SERPINE1 (0.64) SERPINE1HPSEPYGLPYGMGALK1
SCHEMBL2269555 0.86 HPSE (0.55) SERPINE1HPSEPYGLPYGMGALK1
SCHEMBL2292513 0.86 SERPINE1 (0.62) SERPINE1HPSEGALK1CASP6MCL1
SCHEMBL2267915 0.85 SERPINE1 (0.58) SERPINE1HPSEPRSS12
SCHEMBL2274965 0.85 L3MBTL1 (0.49) SERPINE1HPSETDP1CYP2C9CYP2C19
SCHEMBL2275201 0.85 ACLY (0.67) SERPINE1PYGLPYGMPRSS12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 SERPINE1 101/4885HPSE 1324/4885PYGL 1834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.