SCHEMBL2275310

SCHEMBL2275310

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1cc(-c2ccccc2)ncn1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 7/20 0.51
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
GFER P55789 1/20 0.43
SMO Q99835 1/20 0.43
HCAR2 Q8TDS4 2/20 0.43
MMP13 P45452 1/20 0.42
ACLY P53396 3/20 0.42
CYP2C9 P11712 2/20 0.41
CYP2C8 P10632 1/20 0.41
NPC1 O15118 1/20 0.41
ALDH1A1 P00352 1/20 0.41
TP53 P04637 1/20 0.41
CYP1A2 P05177 1/20 0.41
HPGD P15428 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
RECQL P46063 1/20 0.41
BLM P54132 1/20 0.41
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270217 0.85 ACLY (0.58) KMOMEN1KMT2AGFERSMO
SCHEMBL2268181 0.81 MAPT (0.52) MEN1KMT2AHCAR2CYP2C9NPC1
SCHEMBL2278060 0.80 KMO (0.51) KMOCYP2C9NPC1CYP1A2RAB9A
SCHEMBL2271944 0.79 MAPT (0.55) GFERALDH1A1TP53
SCHEMBL2273281 0.79 MEN1 (0.53) MEN1KMT2AGFERHCAR2ACLY
SCHEMBL2271421 0.77 DHODH (0.63) MEN1KMT2AACLYNPC1RAB9A
SCHEMBL2275929 0.77 KMT2A (0.62) MEN1KMT2AACLYTDP1
SCHEMBL2272111 0.75 SUCNR1 (0.59) MEN1KMT2AHCAR2ACLYTDP1
SCHEMBL2275852 0.75 MEN1 (0.55) MEN1KMT2ASMOHCAR2NPC1
SCHEMBL2271790 0.74 SMN1; SMN2 (0.56) MEN1KMT2ACYP2C9NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KMO 194/4885MEN1 3105/4885KMT2A 1669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.