SCHEMBL2278060

SCHEMBL2278060

O=C(Nc1cc(Oc2ccccc2)ccc1C(=O)O)c1cc(-c2ccccc2)ncn1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KMO O15229 3/20 0.51
MET P08581 1/20 0.51
PYGL P06737 6/20 0.47
PYGM P11217 6/20 0.47
KDR P35968 1/20 0.46
SERPINE1 P05121 1/20 0.46
ADORA3 P0DMS8 1/20 0.44
DHODH Q02127 1/20 0.44
NPC1 O15118 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270217 0.85 ACLY (0.58) KMODHODH
SCHEMBL2275310 0.80 KMO (0.51) KMOMETNPC1CYP1A2CYP2C9
SCHEMBL2272800 0.79 HTT (0.52) SERPINE1
SCHEMBL2274064 0.79 TP53 (0.52) SERPINE1ADORA3
SCHEMBL2272461 0.78 SMN1; SMN2 (0.55) SERPINE1DHODHCYP2C9CYP2C19RAB9A
SCHEMBL2270621 0.77 GALK1 (0.68) PYGLPYGMSERPINE1DHODHNPC1
SCHEMBL2273000 0.77 CHEK1 (0.57) PYGLPYGMNPC1RAB9ASMN1; SMN2
SCHEMBL2271588 0.77 SERPINE1 (0.64) PYGLPYGMSERPINE1NPC1RAB9A
SCHEMBL2275544 0.75 FABP1 (0.61) PYGMSERPINE1NPC1RAB9A
SCHEMBL2269563 0.75 STK39 (0.57) PYGLSERPINE1CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 KMO 194/4885MET 1372/4885PYGL 1834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.