SCHEMBL2276277

SCHEMBL2276277

O=C(Nc1cc(CCc2ccccc2)ccc1C(=O)O)c1cccs1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.54
RAB9A P51151 3/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
CYP1A2 P05177 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
GPR174 Q9BXC1 1/20 0.52
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
KDM4E B2RXH2 2/20 0.50
MAPT P10636 2/20 0.50
ALDH1A1 P00352 2/20 0.50
TRPA1 O75762 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
HDAC3 O15379 1/20 0.49
HDAC1 Q13547 1/20 0.49
HPGD P15428 1/20 0.49
TP53 P04637 1/20 0.49
LMNA P02545 1/20 0.48
TDP1 Q9NUW8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2275929 0.81 KMT2A (0.62) MEN1KMT2AMAPTHDAC1TDP1
SCHEMBL2269832 0.81 HDAC3 (0.74) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL2277719 0.80 HDAC1 (0.52) MEN1KMT2AHDAC3HDAC1
SCHEMBL38652227 0.80 RAB9A (0.74) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL13701150 0.80 RAB9A (0.74) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL1307641 0.79 KCNMA1 (0.71) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL1307665 0.79 NPC1 (0.58) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL2276347 0.79 MEN1 (0.56) SMN1; SMN2MEN1KMT2ALMNATDP1
SCHEMBL2269795 0.79 SLC16A3 (0.55) NPC1RAB9AMEN1KMT2ATDP1
SCHEMBL2270880 0.78 ALOX15 (0.60) NPC1RAB9AMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 NPC1 4836/4885RAB9A 2238/4885SMN1; SMN2 3544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.