Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 known ✓ | P39086 | 5/20 | 0.33 |
| ▸ | GRIK2 known ✓ | Q13002 | 3/20 | 0.33 |
| ▸ | GRIA2 known ✓ | P42262 | 1/20 | 0.32 |
| ▸ | GRIA4 known ✓ | P48058 | 1/20 | 0.32 |
| ▸ | GRIK3 known ✓ | Q13003 | 1/20 | 0.32 |
| ▸ | GRIK5 known ✓ | Q16478 | 1/20 | 0.32 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.55 |
| ▸ | NOS3 | P29474 | 2/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.49 |
| ▸ | NOS2 | P35228 | 2/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 6/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 5/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 5/20 | 0.39 |
| ▸ | BHMT | Q93088 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL22800507 | 0.98 | SLC7A5 (0.56) | SLC7A5NOS3NOS1NOS2SLC1A2 | |
| Creatine SCHEMBL18862867 | 0.84 | NOS3 (0.54) | SLC7A5NOS3NOS1NOS2SLC1A2 | |
| Creatine SCHEMBL18862868 | 0.84 | NOS3 (0.54) | SLC7A5NOS3NOS1NOS2SLC1A2 | |
| Creatine SCHEMBL7128868 | 0.84 | NOS3 (0.49) | SLC7A5NOS3NOS1NOS2BHMT | |
| Creatine SCHEMBL28272896 | 0.82 | NOS3 (0.50) | SLC7A5NOS3NOS1NOS2BHMT | |
| Creatine SCHEMBL29019852 | 0.82 | NOS3 (0.43) | NOS3NOS1NOS2 | |
| Creatine SCHEMBL20919747 | 0.81 | NOS2 (0.54) | SLC7A5NOS3NOS1NOS2SLC1A2 | |
| Creatine SCHEMBL21810557 | 0.80 | NOS3 (0.44) | NOS3NOS1NOS2 | |
| Creatine SCHEMBL53010 | 0.80 | NOS3 (0.44) | NOS3NOS1NOS2 | |
| Creatine SCHEMBL4269042 | 0.80 | NOS3 (0.44) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11246846-B2 | Trisodium citrate compositions having enhanced uptake across digestive mucosa | TEMPESTA MICHAEL S (US) | 2022-02-15 | — | — | US | disclosed |
| US-20200397729-A1 | TRISODIUM CITRATE COMPOSITIONS HAVING ENHANCED UPTAKE ACROSS DIGESTIVE MUCOSA | TEMPESTA MICHAEL S (US) | 2020-12-24 | — | — | US | disclosed |