Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.39 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | MMP9 | P14780 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 3/20 | 0.35 |
| ▸ | MMP8 | P22894 | 3/20 | 0.35 |
| ▸ | MMP13 | P45452 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10829033 | 0.70 | ALDH1A1 (0.40) | MMP9MMP2KMT2AALDH1A1CYP1A2 | |
| SCHEMBL6938729 | 0.67 | MMP9 (0.47) | MAOAMAOBMMP9MMP2MMP8 | |
| SCHEMBL2493938 | 0.67 | MMP2 (0.36) | MMP9MMP2MMP8MMP13CYP3A4 | |
| SCHEMBL9557447 | 0.65 | — | — | |
| SCHEMBL7064203 | 0.62 | — | — | |
| SCHEMBL5448618 | 0.62 | MMP9 (0.64) | MMP9MMP2MMP8MMP13CYP3A4 | |
| SCHEMBL4174555 | 0.62 | CYP3A4 (0.49) | MMP9MMP2MMP8MMP13CYP3A4 | |
| SCHEMBL2516164 | 0.61 | — | — | |
| SCHEMBL5006824 | 0.60 | CYP3A4 (0.36) | MMP9MMP2MMP8MMP13CYP3A4 | |
| SCHEMBL7097777 | 0.60 | ALDH1A1 (0.60) | MMP9MMP2MMP8MMP13CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858909-B1 | SYNTHESIS OF OLIGONUCLEOTIDES | GIRINDUS AG (DE) | 2014-09-10 | — | — | EP | disclosed |
| EP-1828218-B1 | SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR | GIRINDUS AG (DE) | 2014-04-30 | — | — | EP | disclosed |
| US-20130303745-A1 | Synthesis of oligonucleotides | LANGE MEINOLF (DE) | 2013-11-14 | — | — | US | disclosed |
| US-20130281682-A1 | SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR | GIRINDUS AG (DE) | 2013-10-24 | — | — | US | disclosed |
| US-20120322994-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | GIRINDUS AG (DE) | 2012-12-20 | — | — | US | disclosed |
| US-20120316328-A1 | SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR | GIRINDUS AG (DE) | 2012-12-13 | — | — | US | disclosed |
| US-20110201799-A1 | Synthesis of oligonucleotides | GIRINDUS AG (DE) | 2011-08-18 | — | — | US | disclosed |
| US-20110065909-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | GIRINDUS AG (DE) | 2011-03-17 | — | — | US | disclosed |
| US-20100081802-A1 | Synthesis of Phosphitylated Compounds Using a Quaternary Heterocyclic Activator | GIRINDUS AG (DE) | 2010-04-01 | — | — | US | disclosed |
| EP-2152723-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | Girindus AG (DE) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008141682-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | GIRINDUS AG (DE) | 2008-11-27 | — | — | WO | disclosed |
| EP-1858909-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | Girindus AG (DE) | 2007-11-28 | — | — | EP | disclosed |
| EP-1828218-A1 | SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR | Girindus AG (DE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006094963-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | GIRINDUS AG (DE) | 2006-09-14 | — | — | WO | disclosed |
| WO-2006064039-A1 | SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR | GIRINDUS AG (DE) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201799-A1 | Synthesis of oligonucleotides | POLR2H, RNGTT, RNASEL | MAOA 2074/4885MAOB 1699/4885MMP9 4730/4885 |
| US-20110065909-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | RNGTT, CPSF1, CPSF6 | MAOA 1331/4885MAOB 1435/4885MMP9 4203/4885 |
| US-20100081802-A1 | Synthesis of Phosphitylated Compounds Using a Quaternary Heterocyclic Activator | ARAF, ATIC, PFKFB3 | MAOA 2977/4885MAOB 3382/4885MMP9 4849/4885 |
| US-20130303745-A1 | Synthesis of oligonucleotides | RNGTT, POLRMT, CPSF6 | MAOA 2097/4885MAOB 2044/4885MMP9 4556/4885 |
| US-20120316328-A1 | SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR | ARAF, ATIC, PFKFB3 | MAOA 3171/4885MAOB 3590/4885MMP9 4825/4885 |
| US-20120322994-A1 | SYNTHESIS OF OLIGONUCLEOTIDES | RNGTT, CPSF1, CPSF6 | MAOA 1331/4885MAOB 1435/4885MMP9 4203/4885 |
| US-20130281682-A1 | SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING A QUATERNARY HETEROCYCLIC ACTIVATOR | ARAF, ATIC, HK2 | MAOA 3254/4885MAOB 3634/4885MMP9 4836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.