Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 3/20 | 0.39 |
| ▸ | TYMS | P04818 | 2/20 | 0.38 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2281293 | 0.93 | POLB (0.41) | TK1TYMS | |
| SCHEMBL2276807 | 0.89 | LMNA (0.34) | TK1 | |
| SCHEMBL14217397 | 0.88 | TK1 (0.33) | TK1 | |
| SCHEMBL12373094 | 0.87 | TOP2A (0.36) | — | |
| SCHEMBL2282272 | 0.85 | BCHE (0.32) | — | |
| SCHEMBL6528397 | 0.84 | BCHE (0.31) | TK1 | |
| SCHEMBL12373098 | 0.83 | — | — | |
| SCHEMBL2282315 | 0.79 | POLB (0.39) | TK1 | |
| SCHEMBL2281348 | 0.78 | POLB (0.46) | TK1 | |
| SCHEMBL24922883 | 0.77 | LMNA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835625-B2 | Propargyl substituted nucleoside compounds and methods | APPLIED BIOSYSTEMS, LLC (US) | 2014-09-16 | — | — | US | disclosed |
| US-8835625-B2 | Propargyl substituted nucleoside compounds and methods | APPLIED BIOSYSTEMS, LLC (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120309953-A1 | Propargyl Substituted Nucleoside Compounds and Methods | Life Technologies Corporation (US) | 2012-12-06 | — | — | US | disclosed |
| US-7998706-B2 | Pyrimidine nucleobases | APPLIED BIOSYSTEMS, LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998706-B2 | Pyrimidine nucleobases | APPLIED BIOSYSTEMS, LLC (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100113759-A1 | PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS | Life Technologies Corporation (US) | 2010-05-06 | — | — | US | disclosed |
| US-20100113759-A1 | PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS | Life Technologies Corporation (US) | 2010-05-06 | — | — | US | disclosed |
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| US-20050214843-A1 | Pyrimidine nucleobases | APPLERA CORPORATION (US) | 2005-09-29 | — | — | US | disclosed |
| US-20050170388-A1 | Pyrimidine nucleobases | APPLERA CORPORATION (US) | 2005-08-04 | — | — | US | disclosed |
| WO-2005063787-A2 | PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS | APPLERA CORPORATION (US) | 2005-07-14 | — | — | WO | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113759-A1 | PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS | PNP, NT5C3B, NUDT1 | TK1 342/4885TYMS 20/4885DNPH1 221/4885 |
| US-20050170388-A1 | Pyrimidine nucleobases | DPYD, PNP, UMPS | TK1 123/4885TYMS 4/4885DNPH1 290/4885 |
| US-20120309953-A1 | Propargyl Substituted Nucleoside Compounds and Methods | PNP, NUDT1, DUT | TK1 85/4885TYMS 33/4885DNPH1 170/4885 |
| US-20050214843-A1 | Pyrimidine nucleobases | DPYD, PNP, UMPS | TK1 123/4885TYMS 4/4885DNPH1 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.