SCHEMBL2287677

SCHEMBL2287677

FC(F)(F)c1c[c]cc(C(F)(F)F)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.33
P2RX7 Q99572 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1804500 0.87 NOTUM (0.34) NOTUM
SCHEMBL2285200 0.85 HTR2A (0.32)
SCHEMBL2286167 0.84 P2RX7 (0.32) P2RX7
SCHEMBL2288952 0.84 ENPP3 (0.32) P2RX7
SCHEMBL2291144 0.79 HTR2A (0.34)
SCHEMBL28866741 0.76 ALDH1A1 (0.49)
SCHEMBL2290046 0.75
SCHEMBL2282265 0.75 NOTUM (0.38) NOTUM
SCHEMBL395629 0.74 NOTUM (0.30) NOTUM
SCHEMBL2286259 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 140 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014131837-A1 ISOXALINE DERIVATIVES FOR USE IN COTTON PLANTS SYNGENTA PARTICIPATIONS AG (CH) 2014-09-04 WO claimed
US-20240172751-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2024-05-30 US disclosed
US-11930816-B2 Methods of pest control in soybean SYNGENTA PARTICIPATIONS AG (CH) 2024-03-19 US disclosed
EP-3792251-B1 NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS ELANCO TIERGESUNDHEIT AG (CH) 2024-02-14 EP disclosed
US-20230320357-A1 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2023-10-12 US disclosed
US-11046659-B2 1,2,3-triazole derivative and insecticide and acaricide containing said derivative as active ingredient HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 2021-06-29 US disclosed
EP-3186227-B1 NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS ELANCO TIERGESUNDHEIT AG (CH) 2021-03-24 EP disclosed
EP-3792251-A1 NOVEL SULFONYLAMINOBENZAMIDE COMPOUNDS AS ANTHELMINTICS Elanco Tiergesundheit AG (CH) 2021-03-17 EP disclosed
US-10869477-B2 Insecticidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2020-12-22 US disclosed
US-10710991-B2 Process for the preparation of thietane derivatives SYNGENTA PARTICIPATIONS AG (CH) 2020-07-14 US disclosed
WO-2012163959-A1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2012-12-06 WO disclosed
WO-2012156400-A1 INSECTICIDAL COMPOUNDS BASED ON ARYLTHIOACETAMIDE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2012-11-22 WO disclosed
WO-2012104331-A2 METHODS OF PEST CONTROL IN SOYBEAN SYNGENTA PARTICIPATIONS AG (CH) 2012-08-09 WO disclosed
US-7989394-B2 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane compounds BASF SE (DE) 2011-08-02 US disclosed
US-20090131256-A1 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds BASF SE (DE) 2009-05-21 US disclosed
US-6878663-B2 Method for producing palladium complex compound CENTRAL GLASS COMPANY, LIMITED (JP) 2005-04-12 US disclosed
EP-1008601-B1 Method for producing palladium complex compound CENTRAL GLASS CO LTD (JP) 2005-03-09 EP disclosed
US-6706905-B1 REACTING AROMATIC COMPOUND, PALLADIUM(II) COMPOUND, AND PHOSPHINE DERIVATIVE; COMPLEXING WITH BENZOIC ACID DERIVATIVE; METALLIZATION CENTRAL GLASS COMPANY, LIMITED (JP) 2004-03-16 US disclosed
US-20020111482-A1 Method for producing palladium complex compound CENTRAL GLASS COMPANY, LIMITED 2002-08-15 US disclosed
EP-1008601-A2 Method for producing palladium complex compound Central Glass Company, Limited (JP) 2000-06-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11930816-B2 Methods of pest control in soybean HRH3, CBR3, H1-2 NOTUM 1363/4885P2RX7 3318/4885
US-10869477-B2 Insecticidal compounds CBR3, C1R, C1S NOTUM 1481/4885P2RX7 309/4885
US-20020111482-A1 Method for producing palladium complex compound PDCD1LG2, CD274, PDCD1 NOTUM 3871/4885P2RX7 1320/4885
US-20240172751-A1 METHODS OF PEST CONTROL IN SOYBEAN BTF3, KEAP1, HAX1 NOTUM 1935/4885P2RX7 2233/4885
US-11046659-B2 1,2,3-triazole derivative and insecticide and acaricide containing said derivative as active ingredient AADAC, CYP51A1, NAT1 NOTUM 43/4885P2RX7 1097/4885
US-10710991-B2 Process for the preparation of thietane derivatives CYP4B1, CYP1B1, CYP1A1 NOTUM 1494/4885P2RX7 983/4885
US-20090131256-A1 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds AAAS, AIPL1, ATXN2 NOTUM 891/4885P2RX7 2072/4885
US-20230320357-A1 METHODS OF PEST CONTROL IN SOYBEAN BTF3, KEAP1, HAX1 NOTUM 1935/4885P2RX7 2233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.