Sugi Predict

Sugi Predict / Compounds / SCHEMBL229039

SCHEMBL229039

SCHEMBL229039

Cn1c(CCCC(=O)O)nc2cc(N(CCO)CCO)ccc21

nearest known ligand 0.82

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ HDAC6 Q9UBN7 8/20 0.82
▸ HDAC1 Q13547 4/20 0.82
▸ HDAC3 O15379 2/20 0.82
▸ HDAC4 P56524 2/20 0.82
▸ HDAC2 Q92769 2/20 0.82
▸ HDAC8 Q9BY41 2/20 0.82
▸ HDAC5 Q9UQL6 2/20 0.82
▸ PTGS1 P23219 1/20 0.82
▸ HDAC10 Q969S8 1/20 0.82
▸ MEN1 O00255 1/20 0.51
▸ RECQL P46063 1/20 0.51
▸ KMT2A Q03164 1/20 0.51
▸ ALDH1A1 P00352 1/20 0.49
▸ PKM P14618 1/20 0.49
▸ F2 P00734 8/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29988092 1.00 HDAC6 (0.82) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL28538533 0.96 HDAC6 (0.75) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL30714411 0.95 HDAC6 (0.92) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL226988 0.95 HDAC6 (0.92) HDAC6HDAC1HDAC3HDAC4HDAC2
Hydrochloric Acid SCHEMBL2783279 0.94 HDAC6 (0.90) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL12102424 0.93 HDAC6 (0.71) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL15396385 0.92 HDAC6 (0.70) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL14700719 0.91 HDAC6 (0.69) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL19191575 0.91 HDAC6 (0.82) HDAC6HDAC1HDAC3HDAC4HDAC2
SCHEMBL16544776 0.91 HDAC6 (0.68) HDAC6HDAC1HDAC3HDAC4HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2970143-B1 PROCESS FOR PREPARING ALKYL ESTERS OF 4-(5-(BIS(2-HYDROXYETHYL) AMINO)-1-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BUTYRIC ACID JOHNSON MATTHEY PLC (GB) 2022-11-09 — — EP claimed
US-10252999-B2 Process for preparing alkyl esters of 4-(5-(bis(2-hydroxyethyl)amino-1-methyl-1H-benzo[D]imidazol-2-yl)butyric acid JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2019-04-09 — — US claimed
US-20180105499-A1 PROCESS FOR PREPARING ALKYL ESTERS OF 4-(5-(BIS(2-HYDROXYETHYL)AMINO-1-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BUTYRIC ACID MACFARLAN SMITH LIMITED (GB) 2018-04-19 — — US claimed
EP-2985038-A1 Lyophilized API preparation Azad Pharma AG (CH) 2016-02-17 — — EP claimed
EP-2970143-A1 PROCESS FOR PREPARING ALKYL ESTERS OF 4-(5-(BIS(2-HYDROXYETHYL) AMINO)-1-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BUTYRIC ACID Johnson Matthey Public Limited Company (GB) 2016-01-20 — — EP claimed
WO-2014140878-A1 PROCESS FOR PREPARING ALKYL ESTERS OF 4-(5-(BIS(2-HYDROXYETHYL) AMINO)-1-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BUTYRIC ACID JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2014-09-18 — — WO claimed
US-20140275567-A1 PROCESS FOR PREPARING ALKYL ESTERS OF 4-(5-(BIS(2-HYDROXYETHYL)AMINO)-1-METHYL-1H-BENZO[D]IMIDAZOL-2-YL)BUTYRIC ACID JOHNSON MATTHEY PLC (GB) 2014-09-18 — — US claimed
EP-3836921-B1 LIQUID BENDAMUSTINE PHARMACEUTICAL COMPOSITIONS HOSPIRA AUSTRALIA PTY LTD (AU) 2025-10-08 — — EP disclosed
US-12246007-B2 Liquid bendamustine pharmaceutical compositions HOSPIRA AUSTRALIA PTY LTD (AU) 2025-03-11 — — US disclosed
US-11826466-B2 Bendamustine solution formulations NAVINTA, LLC (US) 2023-11-28 — — US disclosed
US-11826466-B2 Bendamustine solution formulations NAVINTA, LLC (US) 2023-11-28 — — US disclosed
US-20230364017-A1 BENDAMUSTINE SOLID DISPERSIONS AND CONTINUOUS INFUSION VOUDOURIS VASILIOS (US) 2023-11-16 — — US disclosed
US-20230310381-A1 BENDAMUSTINE PHARMACEUTICAL COMPOSITIONS VOUDOURIS VASILIOS (US) 2023-10-05 — — US disclosed
US-20120003309-A1 Solid Dosage Forms Of Bendamustine ASTELLAS DEUTSCHLAND GMBH (DE) 2012-01-05 — — US disclosed
US-20120003309-A1 Solid Dosage Forms Of Bendamustine ASTELLAS DEUTSCHLAND GMBH (DE) 2012-01-05 — — US disclosed
US-20120003305-A1 Oral Dosage Forms Of Bendamustine ASTELLAS DEUTSCHLAND GMBH (DE) 2012-01-05 — — US disclosed
WO-2011103150-A2 LYOPHILIZED PREPARATIONS OF BENDAMUSTINE CEPHALON, INC. (US) 2011-08-25 — — WO disclosed
WO-2011079193-A2 PREPARATION OF BENDAMUSTINE AND ITS SALTS DR. REDDY'S LABORATORIES LTD. (IN) 2011-06-30 — — WO disclosed
WO-2010063476-A2 SOLID DOSAGE FORMS OF BENDAMUSTINE ASTELLAS DEUTSCHLAND GMBH (DE) 2010-06-10 — — WO disclosed
WO-2010063493-A1 ORAL DOSAGE FORMS OF BENDAMUSTINE ASTELLAS DEUTSCHLAND GMBH (DE) 2010-06-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120003305-A1 Oral Dosage Forms Of Bendamustine TAS2R42, TAS2R40, TAS2R45 HDAC6 1882/4885HDAC1 2640/4885HDAC3 2999/4885
US-11826466-B2 Bendamustine solution formulations BHMT, BHMT2, BAD HDAC6 1244/4885HDAC1 1909/4885HDAC3 3451/4885
US-12246007-B2 Liquid bendamustine pharmaceutical compositions JAK2, SLCO4C1, FGFR3 HDAC6 673/4885HDAC1 2962/4885HDAC3 2873/4885
US-20230310381-A1 BENDAMUSTINE PHARMACEUTICAL COMPOSITIONS FLT3, BLK, FOLR2 HDAC6 1308/4885HDAC1 3917/4885HDAC3 4356/4885
US-20120003309-A1 Solid Dosage Forms Of Bendamustine SORD, SI, SELL HDAC6 122/4885HDAC1 182/4885HDAC3 428/4885
US-20230364017-A1 BENDAMUSTINE SOLID DISPERSIONS AND CONTINUOUS INFUSION WEE1, SLC29A2, SLC29A1 HDAC6 1618/4885HDAC1 2772/4885HDAC3 4295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.