SCHEMBL2291118

SCHEMBL2291118

Cc1cc(C)cc(C[Mg]Cl)c1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.35
TSHR P16473 1/20 0.35
PGK1 P00558 1/20 0.33
PGK2 P07205 1/20 0.33
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
TAAR1 Q96RJ0 1/20 0.32
IDH1 O75874 1/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
HTT P42858 1/20 0.31
RECQL P46063 1/20 0.31
RAB9A P51151 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
HSP90AA1 P07900 1/20 0.30
CCR6 P51684 1/20 0.30
NR3C1 P04150 1/20 0.30
PGR P06401 1/20 0.30
NR3C2 P08235 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL559361 0.77 TAAR1 (0.55) CYP11B1CYP11B2TAAR1MAPT
SCHEMBL1004333 0.74 ALDH1A1 (0.39) ALDH1A1TSHRPGK1PGK2CYP11B1
SCHEMBL560202 0.74 CYP1A2 (0.48) ALDH1A1TSHRCYP11B1CYP11B2TAAR1
SCHEMBL5862875 0.72 HRH3 (0.36) ALDH1A1CYP11B1CYP11B2LMNAMAPT
Magnesium Chloride Anhydrous SCHEMBL28163486 0.72 ACHE (0.40) ALDH1A1TSHRPGK1PGK2CYP11B1
SCHEMBL1097510 0.69 ALDH1A1 (0.40) ALDH1A1TSHRPGK1PGK2CYP11B1
SCHEMBL7987789 0.69 CYP1A2 (0.43) ALDH1A1TAAR1LMNAMAPTRAB9A
SCHEMBL1006697 0.69 CYP1A2 (0.37) ALDH1A1LMNAMAPTHTTRAB9A
SCHEMBL2390804 0.69 ALDH1A1 (0.50) ALDH1A1TSHRTAAR1
SCHEMBL14484673 0.68 IDO1 (0.41) TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0343182-B1 ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS, THEIR PRODUCTION AND THEIR USE AS AROMATICS Consortium für elektrochemische Industrie GmbH (DE) 1992-05-06 EP claimed
EP-0343182-A1 ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS, THEIR PRODUCTION AND THEIR USE AS AROMATICS. CONSORTIUM ELEKTROCHEM IND (DE) 1989-11-29 EP claimed
WO-1988005770-A1 ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS THEIR PRODUCTION AND THEIR USE AS AROMATICS Consortium für elektrochemische Industrie GmbH (DE) 1988-08-11 WO claimed
US-7989394-B2 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane compounds BASF SE (DE) 2011-08-02 US disclosed
US-20090131256-A1 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds BASF SE (DE) 2009-05-21 US disclosed
EP-2041089-A1 SUBSTITUTED 1-(AZOLIN-2-YL)-AMINO-2-ARYL-1-HETARYL-ETHANE COMPOUNDS BASF SE (DE) 2009-04-01 EP disclosed
WO-2008000834-A1 SUBSTITUTED 1-(AZOLIN-2-YL)-AMINO-2-ARYL-1-HETARYL-ETHANE COMPOUNDS BASF SE (DE) 2008-01-03 WO disclosed
US-7186864-B2 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2007-03-06 US disclosed
EP-1511716-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2005-03-09 EP disclosed
US-20040010020-A1 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2004-01-15 US disclosed
WO-2003101932-A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2003-12-11 WO disclosed
EP-0702681-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO. INC. (US) 1996-03-27 EP disclosed
WO-1994029309-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO., INC. (US) 1994-12-22 WO disclosed
EP-0343182-B1 ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS, THEIR PRODUCTION AND THEIR USE AS AROMATICS Consortium für elektrochemische Industrie GmbH (DE) 1992-05-06 EP disclosed
EP-0217159-B1 ALDEHYDES, ACETALS, ALCOHOLS AND ETHERS WITH 3-METHYL OR 3,5-DIMETHYLBENZYL GROUPS, THEIR PREPARATION AND THEIR USE AS FRAGRANCE COMPOUNDS Consortium für elektrochemische Industrie GmbH (DE) 1992-01-02 EP disclosed
US-4968668-A Alcohols having 3-methyl or 3,5-dimethyl or 3,5-dimethylphenyl groups, a process for their preparation and a fragrance composition containing same CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1990-11-06 US disclosed
EP-0343182-A1 ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS, THEIR PRODUCTION AND THEIR USE AS AROMATICS. CONSORTIUM ELEKTROCHEM IND (DE) 1989-11-29 EP disclosed
WO-1988005770-A1 ALCOHOLS WITH 3-METHYL OR 3,5-DIMETHYL GROUPS THEIR PRODUCTION AND THEIR USE AS AROMATICS Consortium für elektrochemische Industrie GmbH (DE) 1988-08-11 WO disclosed
US-4710316-A Aldehydes, acetals, alcohols and ethers having 3-methyl- or 3,5-dimethyl-benzyl groups, their manufacture and perfume materials containing same CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1987-12-01 US disclosed
EP-0217159-A2 Aldehydes, acetals, alcohols and ethers with 3-methyl or 3,5-dimethylbenzyl groups, their preparation and their use as fragrance compounds Consortium für elektrochemische Industrie GmbH (DE) 1987-04-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040010020-A1 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof NR3C1, NR3C2, MC2R ALDH1A1 2921/4885TSHR 425/4885PGK1 488/4885
US-20090131256-A1 Substituted 1-(azolin-2-yl)-amino-2-aryl-1-hetaryl-ethane Compounds AAAS, AIPL1, ATXN2 ALDH1A1 1606/4885TSHR 4231/4885PGK1 3777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.