Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 3/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24990754 | 0.85 | TP53BP1 (0.55) | TP53BP1HDAC1HDAC2MTORGRM5 | |
| SCHEMBL14725927 | 0.83 | TP53BP1 (0.54) | TP53BP1HDAC1HDAC2MTORGRM5 | |
| SCHEMBL13381540 | 0.83 | TP53BP1 (0.60) | TP53BP1HDAC1HDAC2MTORGRM5 | |
| SCHEMBL5857587 | 0.81 | HDAC8 (0.61) | GAAKMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL30739865 | 0.80 | GPR139 (0.59) | HDAC1GAAKMT2ASMN1; SMN2HPGD | |
| SCHEMBL1927576 | 0.80 | L3MBTL1 (0.69) | TP53BP1HDAC1HDAC2MTORGRM5 | |
| SCHEMBL13949658 | 0.79 | LOXL2 (0.51) | GAAKMT2AHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL25976159 | 0.79 | GAA (0.78) | TP53BP1HDAC1HDAC2MTORGRM5 | |
| SCHEMBL618128 | 0.78 | GAA (0.63) | HDAC1HDAC2GAAHSD17B10SMN1; SMN2 | |
| SCHEMBL13949637 | 0.78 | RAB9A (0.51) | TP53BP1HDAC1HDAC2MTORGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2163554-B1 | PYRIMIDODIAZEPINONE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2012-08-01 | — | — | EP | disclosed |
| US-7998954-B2 | Pyrimidodiazepinone derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-08-16 | — | — | US | disclosed |
| US-20100190775-A1 | PYRIMIDODIAZEPINONE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD (JP) | 2010-07-29 | — | — | US | disclosed |
| CN-101679447-A | pyrimidodiazepinone derivative | KYOWA HAKKO KIRIN CO LTD | 2010-03-24 | — | — | CN | disclosed |
| EP-2163554-A1 | PYRIMIDODIAZEPINONE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2010-03-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190775-A1 | PYRIMIDODIAZEPINONE DERIVATIVE | KCNJ1, KCNJ11, ADRA1D | TP53BP1 4271/4885HDAC1 120/4885HDAC2 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.