Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.57 |
| ▸ | ABAT | P80404 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13695939 | 1.00 | ALDH5A1 (0.57) | ALDH5A1ABATALDH1A1CA2ESR1 | |
| SCHEMBL3241580 | 0.84 | MEN1 (0.50) | ABATALDH1A1CA2ESR1ESR2 | |
| SCHEMBL12521588 | 0.84 | MIF (0.41) | ALDH1A1CA2ESR1ESR2MEN1 | |
| SCHEMBL20704671 | 0.82 | CYP2A6 (0.57) | ALDH1A1MEN1KMT2ARAB9AMAPT | |
| SCHEMBL21331846 | 0.82 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL510243 | 0.81 | MEN1 (0.49) | ALDH1A1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL510481 | 0.81 | MAOA (0.53) | ALDH1A1MEN1KMT2AKDM4EMAOB | |
| SCHEMBL12447263 | 0.79 | ALDH1A1 (0.42) | ALDH1A1CA2MEN1KMT2ARAB9A | |
| SCHEMBL10331742 | 0.78 | ABAT (0.76) | ALDH5A1ABATALDH1A1CA2ESR1 | |
| SCHEMBL2921318 | 0.78 | HDAC8 (0.43) | ALDH1A1CA2MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140336160-A1 | NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS | PFIZER (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336160-A1 | NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS | PFIZER (US) | 2014-11-13 | — | — | US | disclosed |
| US-20140336160-A1 | NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS | PFIZER (US) | 2014-11-13 | — | — | US | disclosed |
| US-8822439-B2 | Glucocorticoid receptor agonists | PFIZER INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822439-B2 | Glucocorticoid receptor agonists | PFIZER INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-8822439-B2 | Glucocorticoid receptor agonists | PFIZER INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-8481517-B2 | Pyrrolidine compounds,pharmaceutical compositions containing the same, devices containing the same, and methods of treating asthma or chronic obstructive pulmonary disease by administering the same | CHIESI FARMACEUTICI S.P.A. (IT) | 2013-07-09 | — | — | US | disclosed |
| EP-2225256-B1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LTD (GB) | 2013-01-09 | — | — | EP | disclosed |
| EP-2225256-B1 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LTD (GB) | 2013-01-09 | — | — | EP | disclosed |
| EP-2531516-A2 | PREGNANE COMPOUNDS CONDENSED IN POSITION 16,17 WITH A PYROLIDINE RING WITH GLUCOCORTICOID ACTIVITY | Chiesi Farmaceutici S.p.A. (IT) | 2012-12-12 | — | — | EP | disclosed |
| US-20110201580-A1 | PYRROLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-08-18 | — | — | US | disclosed |
| WO-2011095535-A2 | PYRROLIDINE DERIVATIVES | CHIESI FARMACEUTICI S.P.A. (IT) | 2011-08-11 | — | — | WO | disclosed |
| EP-2225256-A2 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | Pfizer Limited (GB) | 2010-09-08 | — | — | EP | disclosed |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2009-09-10 | — | — | US | disclosed |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2009-09-10 | — | — | US | disclosed |
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | GLOSSOP PAUL ALAN | 2009-09-10 | — | — | US | disclosed |
| WO-2009069032-A2 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009069032-A2 | NOVEL GLUCOCORTICOID RECEPTOR AGONISTS | PFIZER LIMITED (GB) | 2009-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227548-A1 | Novel Glucocorticoid Receptor Agonists | NR3C1, NR3C2, MC2R | ALDH5A1 4073/4885ABAT 3288/4885ALDH1A1 2013/4885 |
| US-20140336160-A1 | NOVEL GLUCOCORTICOLD RECEPTOR AGONISTS | NR3C1, TSLP, MRGPRX2 | ALDH5A1 4194/4885ABAT 3712/4885ALDH1A1 2281/4885 |
| US-20110201580-A1 | PYRROLIDINE DERIVATIVES | IL5, TSLP, NR3C1 | ALDH5A1 970/4885ABAT 1360/4885ALDH1A1 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.