Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | FADS1 | O60427 | 3/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2998001 | 0.83 | HTR7 (0.41) | CTSGCMA1KCNH2 | |
| SCHEMBL3005601 | 0.81 | ALDH1A1 (0.41) | ALOX5 | |
| SCHEMBL3001653 | 0.80 | NPC1 (0.41) | — | |
| SCHEMBL3006660 | 0.80 | POLB (0.41) | ALOX5FADS1METAP1 | |
| SCHEMBL3002692 | 0.80 | L3MBTL1 (0.50) | ALOX5NOTUM | |
| SCHEMBL2996862 | 0.78 | MGLL (0.38) | ALOX5NOTUM | |
| SCHEMBL3003653 | 0.77 | KMT2A (0.46) | ALOX5CTSGCMA1 | |
| SCHEMBL16480396 | 0.77 | FADS1 (0.48) | ALOX5NSD2NOTUMDRD2DRD3 | |
| SCHEMBL3001196 | 0.76 | HTR7 (0.47) | ALOX5NOTUM | |
| SCHEMBL3002934 | 0.76 | NOTUM (0.41) | NOTUMDRD2DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | claimed |
| EP-1608655-B8 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | BRANE DISCOVERY SRL IN LIQUIDA (IT) | 2008-10-15 | — | — | EP | claimed |
| EP-1608655-B1 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH SRL (IT) | 2008-07-16 | — | — | EP | claimed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | claimed |
| EP-1608655-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2005-12-28 | — | — | EP | claimed |
| WO-2004085438-A2 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH S.R.L. (IT) | 2004-10-07 | — | — | WO | claimed |
| EP-2857017-B1 | Use of dimiracetam in the treatment of chronic pain | NEUROTUNE AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| EP-2857017-A2 | Use of dimiracetam in the treatment of chronic pain | Neurotune AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| EP-2146706-B1 | USE OF DIMIRACETAM IN THE TREATMENT OF CHRONIC PAIN | NEUROTUNE AG (CH) | 2015-02-25 | — | — | EP | disclosed |
| EP-2620149-A2 | Use of dimiracetam in the treatment of chronic pain | Neurotune AG (CH) | 2013-07-31 | — | — | EP | disclosed |
| US-8222241-B2 | Use of dimiracetam in the treatment of chronic pain | NEUROTUNE AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110251250-A1 | USE OF DIMIRACETAM IN THE TREATMENT OF CHRONIC PAIN | FARINA CARLO | 2011-10-13 | — | — | US | disclosed |
| US-7989421-B2 | Use of dimiracetam in the treatment of chronic pain | NEUROTUNE AG (CH) | 2011-08-02 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | FARINA CARLO | 2009-06-25 | — | — | US | disclosed |
| US-7544705-B2 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2009-06-09 | — | — | US | disclosed |
| WO-2008125674-A1 | USE OF DIMIRACETAM IN THE TREATMENT OF CHRONIC PAIN | NEUROTUNE AG (CH) | 2008-10-23 | — | — | WO | disclosed |
| EP-1608655-B1 | PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS | NIKEM RESEARCH SRL (IT) | 2008-07-16 | — | — | EP | disclosed |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | NEUROTUNE AG (CH) | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251250-A1 | USE OF DIMIRACETAM IN THE TREATMENT OF CHRONIC PAIN | DIMT1, OPRK1, OPRM1 | ALOX5 1515/4885NSD2 1565/4885NOTUM 820/4885 |
| US-20090163565-A1 | Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof | OPRL1, GRIN3B, GRIN3A | ALOX5 571/4885NSD2 3112/4885NOTUM 696/4885 |
| US-20070027137-A1 | Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents | GRIN3A, GRIN1, GRIN3B | ALOX5 467/4885NSD2 2438/4885NOTUM 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.