Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 3/20 | 0.60 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23022833 | 0.90 | PPM1D (0.50) | PPM1DROCK2SIGMAR1PKN2CXCR4 | |
| SCHEMBL23004942 | 0.83 | SLC7A5 (0.47) | PPM1DSLC7A5ROCK2SIGMAR1CXCR4 | |
| SCHEMBL2197290 | 0.82 | CYP4F2 (0.61) | PPM1DLOXL2CYP4F2CYP4A11SLC7A5 | |
| SCHEMBL21579366 | 0.80 | LOXL2 (0.70) | LOXL2CYP4F2CYP4A11HIF1ASLC7A5 | |
| SCHEMBL23023088 | 0.80 | ALDH1A1 (0.60) | SIGMAR1CXCR4KMT2A | |
| Hydrochloric Acid SCHEMBL16507177 | 0.80 | LMNA (0.49) | LOXL2CYP4A11 | |
| SCHEMBL23023149 | 0.80 | CXCR4 (0.50) | PPM1DSIGMAR1CXCR4 | |
| SCHEMBL28206342 | 0.79 | CYP4F2 (0.68) | LOXL2CYP4F2CYP4A11HIF1ASLC7A5 | |
| SCHEMBL23642786 | 0.79 | CYP4F2 (0.63) | PPM1DLOXL2CYP4F2CYP4A11HIF1A | |
| SCHEMBL23004820 | 0.78 | CXCR4 (0.54) | SIGMAR1CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210053997-A1 | TRNA SYNTHETASE INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053997-A1 | TRNA SYNTHETASE INHIBITORS | TRMT1, AARS1, GARS1 | PPM1D 4169/4885LOXL2 4413/4885CYP4F2 4295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.