Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195263 | 0.92 | AKR1C1 (0.42) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL20592967 | 0.87 | AKR1C1 (0.45) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL4199640 | 0.84 | AKR1C1 (0.40) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL3704068 | 0.83 | AKR1C1 (0.38) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL7082757 | 0.83 | AKR1C1 (0.42) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL6981777 | 0.82 | AKR1C1 (0.41) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL10353787 | 0.79 | AKR1C1 (0.45) | AKR1C1LMNAHTTHDAC4ALDH1A1 | |
| SCHEMBL6982681 | 0.75 | THRB (0.44) | AKR1C1HDAC4ALDH1A1MEN1KMT2A | |
| SCHEMBL6982594 | 0.74 | HSD11B1 (0.39) | AKR1C1HSD11B1MEN1KMT2A | |
| SCHEMBL6967893 | 0.74 | CNR1 (0.40) | AKR1C1ALDH1A1HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140311218-A1 | Methods of Producing Pseudoscent Compositions of Narcotic Materials and Compositions Thereof | ADEBIMPE DAVID (US) | 2014-10-23 | — | — | US | claimed |
| CN-106432542-B | The preparation and application of O-3,4- methylenedioxyphenylacetic acid ester-N- trimethyl chitin quaternary ammonium salt | 湖南工业大学 | 2019-05-24 | — | — | CN | disclosed |
| US-8415350-B2 | Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors | HOFFMANN-LA ROCHE INC. (US) | 2013-04-09 | — | — | US | disclosed |
| US-8183374-B2 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2012-05-22 | — | — | US | disclosed |
| US-20120004208-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | GOBBI LUCA (CH) | 2012-01-05 | — | — | US | disclosed |
| US-20110281890-A1 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-17 | — | — | US | disclosed |
| EP-1978959-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-09 | — | — | EP | disclosed |
| EP-2340835-A1 | Piperidine and piperazine derivatives | M's Science Corporation (JP) | 2011-07-06 | — | — | EP | disclosed |
| EP-1976525-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2010-11-03 | — | — | EP | disclosed |
| US-20100256162-A1 | Piperazine and Piperidine Derivatives | AGY THERAPEUTICS, INC. (US) | 2010-10-07 | — | — | US | disclosed |
| EP-1730292-A2 | USE OF INDANOYL AMIDE TO STIMULATE SECONDARY METABOLISM IN TAXUS SP. | Phyton Biotech, Inc. (US) | 2006-12-13 | — | — | EP | disclosed |
| US-7109377-B2 | Synthesis of combinatorial libraries of compounds reminiscent of natural products | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-09-19 | — | — | US | disclosed |
| US-20050221456-A1 | Use of indanoyl amide to stimulate secondary metabolism in Taxus sp. | PHYTON BIOTECH, INC. (US) | 2005-10-06 | — | — | US | disclosed |
| WO-2005079355-A2 | USE OF INDANOYL AMIDE TO STIMULATE SECONDARY METABOLISM IN TAXUS SP. | PHYTON BIOTECH, INC. (US) | 2005-09-01 | — | — | WO | disclosed |
| US-6448443-B1 | GENERATED FROM DIVERSIFIABLE SCAFFOLDS SYNTHESIZED FROM THE PYRIDINE-BASED TEMPLATE ISONICOTINAMIDE; ALSO PROVIDES A NOVEL ORTHO-NITROBENZYL PHOTOLINKER; SYNTHESIZED FROM A SHIKIMIC ACID BASED EPOXYOL TEMPLATE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2002-09-10 | — | — | US | disclosed |
| EP-1021418-A4 | SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF | COCENSYS INC (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1021418-A1 | SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF | Cocensys, Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5679699-A | ANTIISCHEMIC AGENTS, HEART RATE LOWERING AGENTS | KALI-CHEMIE PHARMA GMBH (DE) | 1997-10-21 | — | — | US | disclosed |
| WO-1997034878-A1 | SUBSTITUTED 2,3-BENZODIAZEPIN-4-ONES AND THE USE THEREOF | COCENSYS, INC. (US) | 1997-09-25 | — | — | WO | disclosed |
| US-5547967-A | HYPOTENSIVE AGENT, ANTIISCHEMIC AGENT | KALI-CHEMIE PHARMA GMBH (DE) | 1996-08-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004208-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HTR2A, HTR3A, HTR2C | AKR1C1 3344/4885OPRM1 53/4885OPRL1 24/4885 |
| US-20110281890-A1 | Piperidine and piperazine derivatives | SIGMAR1, OPRM1, OPRD1 | AKR1C1 3261/4885OPRM1 2/4885OPRL1 5/4885 |
| US-20100256162-A1 | Piperazine and Piperidine Derivatives | SIGMAR1, OPRM1, OPRD1 | AKR1C1 3265/4885OPRM1 2/4885OPRL1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.