Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6896429 | 0.84 | LMNA (0.36) | AKR1C1OPRM1OPRL1LMNAALDH1A1 | |
| SCHEMBL230776 | 0.84 | AKR1C1 (0.45) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL8195263 | 0.81 | AKR1C1 (0.42) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL10353787 | 0.78 | AKR1C1 (0.45) | AKR1C1LMNAHTTHDAC4ALDH1A1 | |
| SCHEMBL20592967 | 0.76 | AKR1C1 (0.45) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL7082757 | 0.73 | AKR1C1 (0.42) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL3704068 | 0.73 | AKR1C1 (0.38) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL6981777 | 0.72 | AKR1C1 (0.41) | AKR1C1OPRM1OPRL1LMNAHTT | |
| SCHEMBL4952380 | 0.69 | LMNA (0.35) | AKR1C1OPRM1OPRL1LMNAALDH1A1 | |
| SCHEMBL6982681 | 0.66 | THRB (0.44) | AKR1C1HDAC4ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4333877-A | Substituted 2,7-dioxo-2,7-dihydrobenzo[1:2-b; 5:6-b1 ]difuran or -dipyrrole dyestuffs, their preparation and their use | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-06-08 | — | — | US | claimed |
| EP-1720851-B1 | PROCESS FOR SYNTHESISING HELIOTROPINE AND ITS DERIVATIVES | ENDURA SPA (IT) | 2009-03-04 | — | — | EP | disclosed |
| US-7402709-B2 | Process for synthesizing heliotropine and its derivatives | ENDURA S.P.A. (IT) | 2008-07-22 | — | — | US | disclosed |
| US-20070100167-A1 | Process for synthesizing heliotropine and its derivatives | ENDURA S.P.A. (IT) | 2007-05-03 | — | — | US | disclosed |
| EP-1720851-A1 | PROCESS FOR SYNTHESISING HELIOTROPINE AND ITS DERIVATIVES | ENDURA S.p.A. (IT) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005042512-A1 | PROCESS FOR SYNTHESISING HELIOTROPINE AND ITS DERIVATIVES | ENDURA S.P.A. (IT) | 2005-05-12 | — | — | WO | disclosed |
| EP-0023080-B1 | SUBSTITUTED 2,7-DIOXO-2,7-DIHYDROBENZO(1:2-B; 5,6-B1)DIFURAN OR DIPYRROLE DYESTUFFS, PROCESSES FOR THEIR PREPARATION AND THEIR USE FOR THE COLOURATION OF AROMATIC POLYESTER TEXTILE MATERIALS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-07-27 | — | — | EP | disclosed |
| US-4333877-A | Substituted 2,7-dioxo-2,7-dihydrobenzo[1:2-b; 5:6-b1 ]difuran or -dipyrrole dyestuffs, their preparation and their use | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-06-08 | — | — | US | disclosed |
| EP-0023080-A1 | Substituted 2,7-dioxo-2,7-dihydrobenzo(1:2-b; 5,6-b1)difuran or dipyrrole dyestuffs, processes for their preparation and their use for the colouration of aromatic polyester textile materials | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-01-28 | — | — | EP | disclosed |
| EP-0002460-B1 | PROCESS FOR THE PREPARATION OF 3,4-METHYLENDIOXYMANDELIC ACID | HAARMANN & REIMER GMBH (DE) | 1980-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070100167-A1 | Process for synthesizing heliotropine and its derivatives | ADH1C, ADH1A, HAO2 | AKR1C1 161/4885OPRM1 34/4885OPRL1 409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.