Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 11/20 | 0.52 |
| ▸ | HTR1A | P08908 | 10/20 | 0.52 |
| ▸ | HTR1D | P28221 | 9/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12247689 | 0.86 | HTR1B (0.60) | HTR1BHTR1AHTR1DGPR84MAPT | |
| SCHEMBL23269429 | 0.82 | HTR1B (0.61) | HTR1BHTR1AHTR1DGPR84MAPT | |
| SCHEMBL23259141 | 0.81 | HTR2A (0.53) | HTR1BHTR1AHTR1DGPR84MAPT | |
| SCHEMBL434877 | 0.80 | GPR84 (0.64) | HTR1BHTR1AHTR1DGPR84MAPT | |
| SCHEMBL736956 | 0.80 | GPR84 (0.64) | HTR1BHTR1AHTR1DGPR84MAPT | |
| SCHEMBL31254072 | 0.79 | HTT (0.52) | HTR1BHTR1AHTR1DKDM4EHTT | |
| SCHEMBL20472271 | 0.79 | HTT (0.52) | HTR1BHTR1AHTR1DKDM4EHTT | |
| SCHEMBL1196544 | 0.79 | HTR1A (0.57) | HTR1BHTR1AHTR1DGPR84MAPT | |
| SCHEMBL18311441 | 0.77 | HTR1B (0.56) | HTR1BHTR1AHTR1DGPR84MAPT | |
| SCHEMBL14960988 | 0.76 | HTR1B (0.63) | HTR1BHTR1AHTR1DMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127266-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2022-04-28 | — | — | US | disclosed |
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | SUN PHARMA ADVANCED RESEARCH COMPANY LTD (IN) | 2021-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210115038-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | HTR1B 4873/4885HTR1A 4870/4885HTR1D 4877/4885 |
| US-20220127266-A1 | MALIC ENZYME INHIBITORS | ME1, ME2, ME3 | HTR1B 4873/4885HTR1A 4870/4885HTR1D 4877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.