Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 3/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | PTPRF | P10586 | 1/20 | 0.31 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.30 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.30 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334798 | 0.89 | PTGER1 (0.39) | PTGER1ADORA2AIKBKB | |
| SCHEMBL2328798 | 0.89 | PTGER1 (0.38) | PTGER1SMN1; SMN2ADORA2AIKBKB | |
| SCHEMBL2329257 | 0.89 | IKBKB (0.43) | PTGER1ADORA2AIKBKB | |
| SCHEMBL1704368 | 0.88 | LRRK2 (0.34) | PTGER1SMN1; SMN2LRRK2PTPRFPTPN2 | |
| SCHEMBL2324749 | 0.87 | IKBKB (0.46) | PTGER1SMN1; SMN2ADORA2AIKBKBCSNK2A1 | |
| SCHEMBL2326938 | 0.85 | LDHA (0.39) | PTGER1ADORA2AIKBKB | |
| SCHEMBL2332003 | 0.85 | FYN (0.39) | SMN1; SMN2LRRK2ADORA2AFYNIKBKB | |
| SCHEMBL2327570 | 0.84 | LRRK2 (0.36) | SMN1; SMN2LRRK2ADORA2AFYNIKBKB | |
| SCHEMBL2332145 | 0.83 | MMP1 (0.38) | PTGER1IKBKB | |
| SCHEMBL1703791 | 0.80 | FPR2 (0.46) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |