Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 6/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP9 | P14780 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334798 | 0.91 | PTGER1 (0.39) | PTGER1LDHAMMP1MMP2MMP9 | |
| SCHEMBL2329257 | 0.90 | IKBKB (0.43) | PTGER1LDHASLC9A1FPR2PTPN11 | |
| SCHEMBL2332145 | 0.90 | MMP1 (0.38) | PTGER1LDHAMMP1MMP2MMP9 | |
| SCHEMBL2327504 | 0.89 | PTGER1 (0.38) | PTGER1SMN1; SMN2ADORA2AIKBKB | |
| SCHEMBL2324749 | 0.89 | IKBKB (0.46) | PTGER1LDHAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2326938 | 0.88 | LDHA (0.39) | PTGER1LDHAFPR2ADORA2AIKBKB | |
| SCHEMBL1704592 | 0.88 | FPR2 (0.37) | PTGER1SLC9A1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2327822 | 0.84 | TRPM8 (0.36) | PTGER1SLC9A1KDM4ESMN1; SMN2TRPM8 | |
| SCHEMBL2332690 | 0.83 | NR4A1 (0.37) | SLC9A1KDM4ESMN1; SMN2TRPM8ALDH1A1 | |
| SCHEMBL1703850 | 0.80 | FPR2 (0.42) | PTGER1SLC9A1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |