Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334798 | 0.92 | PTGER1 (0.39) | MMP1MMP13MMP2MMP9PTGER1 | |
| SCHEMBL2328798 | 0.90 | PTGER1 (0.38) | MMP1MMP13MMP2MMP9PTGER1 | |
| SCHEMBL1703858 | 0.87 | RAB9A (0.33) | MMP1MMP13MMP2MMP9PTGER1 | |
| SCHEMBL2329257 | 0.85 | IKBKB (0.43) | PTGER1LDHAIKBKBNPC1RAB9A | |
| SCHEMBL2327504 | 0.83 | PTGER1 (0.38) | PTGER1IKBKB | |
| SCHEMBL2324749 | 0.83 | IKBKB (0.46) | PTGER1LDHAIKBKBKDM4EALDH1A1 | |
| SCHEMBL2331664 | 0.83 | MAPK14 (0.34) | MAPK14IKBKB | |
| SCHEMBL2326938 | 0.83 | LDHA (0.39) | PTGER1LDHAMAPK14IKBKB | |
| SCHEMBL2329098 | 0.82 | MAPK14 (0.34) | MAPK14IKBKBKDM4EGRM2MAPT | |
| SCHEMBL1703980 | 0.80 | PTGER1 (0.35) | PTGER1IKBKBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | claimed |
| EP-2225231-B1 | AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2011-08-17 | — | — | EP | disclosed |