Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.79 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.35 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 2/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20744604 | 1.00 | HTR6 (0.79) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL20758423 | 0.98 | HTR6 (0.76) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL13073 | 0.98 | HTR6 (0.76) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| Hydrochloric Acid SCHEMBL16110108 | 0.98 | HTR6 (0.76) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| Hydrochloric Acid SCHEMBL16110484 | 0.98 | HTR6 (0.76) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| Hydrochloric Acid SCHEMBL16110110 | 0.98 | HTR6 (0.76) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| Hydrochloric Acid SCHEMBL16108748 | 0.96 | HTR6 (0.73) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL20744481 | 0.95 | HTR6 (0.72) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL12730878 | 0.95 | HTR6 (0.72) | HTR6SLC6A1SLC6A11TSHRLMNA | |
| SCHEMBL3289269 | 0.93 | HTR6 (0.83) | HTR6HTR2BL3MBTL3L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10344006-B2 | Amine-containing acyclic hydrofluoroethers and methods of using the same | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2019-07-09 | — | — | US | disclosed |
| US-10344002-B2 | Compositions and methods for treating metabolic disorders | NUSIRT SCIENCES, INC. (US) | 2019-07-09 | — | — | US | disclosed |
| US-10287286-B2 | Compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2019-05-14 | — | — | US | disclosed |
| US-20190040024-A1 | AMINE-CONTAINING ACYCLIC HYDROFLUOROETHERS AND METHODS OF USING THE SAME | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2019-02-07 | — | — | US | disclosed |
| US-20180105498-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS | NUSIRT SCIENCES, INC. | 2018-04-19 | — | — | US | disclosed |
| US-20180072714-A1 | Novel Compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | US | disclosed |
| CN-103698456-B | Online detection method for pyrolysis gas-phase components of tobacco additive or tobacco material | SHANGHAI TOBACCO GROUP CO LTD | 2015-07-15 | — | — | CN | disclosed |
| CN-103698456-A | Online detection method for pyrolysis gas-phase components of tobacco additive or tobacco material | SHANGHAI TOBACCO GROUP CO LTD | 2014-04-02 | — | — | CN | disclosed |
| US-8618132-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2013-12-31 | — | — | US | disclosed |
| US-20130231321-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2013-09-05 | — | — | US | disclosed |
| US-20110092475-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-04-21 | — | — | US | disclosed |
| US-20110092475-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | H. LUNDBECK A/S (DK) | 2011-04-21 | — | — | US | disclosed |
| US-20090069282-A1 | ALKYNE COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-03-12 | — | — | US | disclosed |
| US-7452911-B2 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2008-11-18 | — | — | US | disclosed |
| EP-1558578-A1 | NOVEL ALKYNE COMPOUNDS HAVING AN MCH ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-08-03 | — | — | EP | disclosed |
| US-20040209865-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-10-21 | — | — | US | disclosed |
| WO-2004039780-A1 | NOVEL ALKYNE COMPOUNDS HAVING AN MCH ANTAGONISTIC EFFECT AND MEDICAMENTS CONTAINING THESE COMPOUNDS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-13 | — | — | WO | disclosed |
| US-5856318-A | Nitrogen-containing cyclohetero cyclo-heteroaminoaryl derivatives for CNS disorders | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-01-05 | — | — | US | disclosed |
| US-5656625-A | ANTIISCHEMIC AGENT, PSYCHOLOGICAL DISORDER, ANTICONVULSANT | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-08-12 | — | — | US | disclosed |
| US-5346908-A | Anticonvulsant | NATIONAL INSTITUTES OF HEALTH (US) | 1994-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072714-A1 | Novel Compounds | F12, HAX1, C1S | HTR6 1000/4885SLC6A1 1828/4885SLC6A11 1806/4885 |
| US-10344002-B2 | Compositions and methods for treating metabolic disorders | LIPC, PC, PNLIP | HTR6 2890/4885SLC6A1 2197/4885SLC6A11 2662/4885 |
| US-20180105498-A1 | COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS | LIPC, PC, PNLIP | HTR6 2890/4885SLC6A1 2197/4885SLC6A11 2662/4885 |
| US-10287286-B2 | Compounds | F12, C1S, F3 | HTR6 872/4885SLC6A1 1306/4885SLC6A11 1454/4885 |
| US-20090069282-A1 | ALKYNE COMPOUNDS WITH MCH ANTAGONISTIC ACTIVITY AND MEDICAMENTS COMPRISING THESE COMPOUNDS | MCHR1, MCHR2, GPR119 | HTR6 175/4885SLC6A1 1980/4885SLC6A11 1750/4885 |
| US-20040209865-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, MCHR2, NPY1R | HTR6 172/4885SLC6A1 1803/4885SLC6A11 2041/4885 |
| US-20130231321-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | SULT1E1, SULT2A1, SULT1A1 | HTR6 2068/4885SLC6A1 332/4885SLC6A11 844/4885 |
| US-10344006-B2 | Amine-containing acyclic hydrofluoroethers and methods of using the same | AFF1, AFF2, FANCF | HTR6 2808/4885SLC6A1 1237/4885SLC6A11 1307/4885 |
| US-20110092475-A1 | 2-SUBSTITUTED-ETHYNYLTHIAZOLE DERIVATIVES AND USES OF SAME | SULT1E1, SULT2A1, SULT1A1 | HTR6 2068/4885SLC6A1 332/4885SLC6A11 844/4885 |
| US-20190040024-A1 | AMINE-CONTAINING ACYCLIC HYDROFLUOROETHERS AND METHODS OF USING THE SAME | AFF1, AFF2, FANCF | HTR6 2808/4885SLC6A1 1237/4885SLC6A11 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.