SCHEMBL23319902

SCHEMBL23319902

COC(=O)c1nnn(Cc2ccc(OC)cc2)c1Oc1ccc(F)cc1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.60
KMT2A Q03164 3/20 0.60
POLB P06746 4/20 0.54
ALOX15 P16050 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
SMN1; SMN2 Q16637 2/20 0.48
CYP1A2 P05177 1/20 0.48
AKR1C3 P42330 2/20 0.46
MAPT P10636 2/20 0.46
RXFP1 Q9HBX9 1/20 0.46
MET P08581 1/20 0.46
HPGD P15428 3/20 0.45
HSD17B10 Q99714 3/20 0.45
ALDH1A1 P00352 3/20 0.44
LMNA P02545 1/20 0.44
KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25463546 0.89 ALOX15 (0.51) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL22815603 0.84 ALOX15 (0.49) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL24155170 0.84 NPBWR1 (0.50) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL28543421 0.82 ALDH1A1 (0.48) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL23320004 0.82 KCNH2 (0.50) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL22815777 0.82 ALOX15 (0.47) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL26089010 0.81 UCHL1 (0.50) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL23319914 0.81 HTR3E (0.48) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL26467790 0.81 SMN1; SMN2 (0.47) MEN1KMT2APOLBALOX15L3MBTL1
SCHEMBL23319950 0.81 PKM (0.47) MEN1KMT2APOLBALOX15L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112399873-B Triazole glycolate oxidase inhibitors 坎特罗治疗有限公司 2024-10-25 CN disclosed
EP-3817816-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS Orfan Biotech Inc. (US) 2021-05-12 EP disclosed
CN-112399873-A Triazole glycolate oxidase inhibitor 奥凡生物科技公司 2021-02-23 CN disclosed