SCHEMBL25463546

SCHEMBL25463546

COC(=O)c1nnn(Cc2ccc(OC)cc2)c1Oc1ccc(Br)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
CYP1A2 P05177 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
POLB P06746 3/20 0.46
AKR1C3 P42330 3/20 0.46
MAPT P10636 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
CYP19A1 P11511 1/20 0.44
HPGD P15428 2/20 0.44
HSD17B10 Q99714 2/20 0.44
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MMP1 P03956 1/20 0.42
MMP9 P14780 1/20 0.42
MMP13 P45452 1/20 0.42
ADAM17 P78536 1/20 0.42
EGFR P00533 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26467790 0.92 SMN1; SMN2 (0.47) ALOX15L3MBTL1CYP1A2SMN1; SMN2MEN1
SCHEMBL22815777 0.91 ALOX15 (0.47) ALOX15L3MBTL1CYP1A2SMN1; SMN2MEN1
SCHEMBL21296900 0.90 CYP19A1 (0.57) ALOX15L3MBTL1SMN1; SMN2MEN1KMT2A
SCHEMBL21296928 0.90 ALOX15 (0.49) ALOX15L3MBTL1CYP1A2SMN1; SMN2MEN1
SCHEMBL26467846 0.90 ALOX15 (0.49) ALOX15L3MBTL1MEN1KMT2APOLB
SCHEMBL23319902 0.89 MEN1 (0.60) ALOX15L3MBTL1CYP1A2SMN1; SMN2MEN1
SCHEMBL22815603 0.84 ALOX15 (0.49) ALOX15L3MBTL1CYP1A2SMN1; SMN2MEN1
SCHEMBL24155170 0.84 NPBWR1 (0.50) ALOX15L3MBTL1CYP1A2SMN1; SMN2MEN1
SCHEMBL23320004 0.82 KCNH2 (0.50) ALOX15L3MBTL1CYP1A2SMN1; SMN2MEN1
SCHEMBL28543421 0.82 ALDH1A1 (0.48) ALOX15L3MBTL1CYP1A2SMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4087836-B1 PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS CANTERO THERAPEUTICS INC (US) 2025-10-08 EP disclosed
CN-114945559-B Preparation method of triazole glycollic acid oxidase inhibitor 坎特罗治疗有限公司 2025-03-11 CN disclosed
CN-112399873-B Triazole glycolate oxidase inhibitors 坎特罗治疗有限公司 2024-10-25 CN disclosed
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 US disclosed
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 US disclosed
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 US disclosed
US-20230129160-A1 PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-04-27 US disclosed
US-20230129160-A1 PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-04-27 US disclosed
EP-4087836-A1 PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS Cantero Therapeutics, Inc. (US) 2022-11-16 EP disclosed
CN-114945559-A Preparation method of triazole glycolate oxidase inhibitor 坎特罗治疗有限公司 2022-08-26 CN disclosed
US-11401246-B2 Triazole glycolate oxidase inhibitors Cantero Therapeutics, Inc. (US) 2022-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11401246-B2 Triazole glycolate oxidase inhibitors XDH, DUOX1, PNPO ALOX15 71/4885L3MBTL1 2586/4885CYP1A2 179/4885
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO ALOX15 71/4885L3MBTL1 2586/4885CYP1A2 179/4885
US-20230129160-A1 PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS TH, AOX1, AOC3 ALOX15 510/4885L3MBTL1 4348/4885CYP1A2 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.