SCHEMBL23330872

SCHEMBL23330872

COc1ccc(C(=O)Nc2cnc(Cl)nc2Cl)cn1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
AHR P35869 1/20 0.48
NNMT P40261 1/20 0.48
GPR35 Q9HC97 1/20 0.45
GPR55 Q9Y2T6 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.43
HDAC1 Q13547 1/20 0.43
PTPN1 P18031 1/20 0.43
P4HTM Q9NXG6 1/20 0.43
ABCG2 Q9UNQ0 2/20 0.42
ABCB1 P08183 1/20 0.42
KDM4E B2RXH2 2/20 0.42
MAPT P10636 1/20 0.42
POLB P06746 1/20 0.42
RORC P51449 1/20 0.41
P2RX3 P56373 1/20 0.41
ALDH1A1 P00352 2/20 0.41
HTT P42858 2/20 0.41
NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23330869 0.85 NNMT (0.47) MEN1KMT2AAHRNNMTGPR35
SCHEMBL23330537 0.84 F10 (0.56) MEN1KMT2ASMN1; SMN2HDAC1KDM4E
SCHEMBL2223715 0.77 TAS1R3 (0.48) MEN1KMT2ASMN1; SMN2KDM4EMAPT
SCHEMBL23331032 0.76 KCNQ3 (0.51) MEN1KMT2AHDAC1P4HTMPOLB
SCHEMBL23330676 0.75 ADORA3 (0.49) MEN1KMT2ASMN1; SMN2KDM4EALDH1A1
SCHEMBL23330837 0.75 KCNMA1 (0.51) KMT2ASMN1; SMN2KDM4EPOLBALDH1A1
SCHEMBL23330651 0.75 HTT (0.58) MEN1KMT2ASMN1; SMN2HDAC1MAPT
SCHEMBL3596711 0.75 RAB9A (0.62) MEN1KMT2ANNMTSMN1; SMN2PTPN1
SCHEMBL3788719 0.74 SMN1; SMN2 (0.64) MEN1KMT2ASMN1; SMN2KDM4EMAPT
SCHEMBL8554348 0.73 TSHR (0.61) MEN1KMT2AAHRSMN1; SMN2HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230028221-A1 EED INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF JING MEDICINE TECHNOLOGY (SHANGHAI) LTD. (CN) 2023-01-26 US disclosed
WO-2021083380-A1 EED INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海科技大学 2021-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230028221-A1 EED INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF CYP4F11, CYP4A11, HSD11B1 MEN1 954/4885KMT2A 3987/4885AHR 3088/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.