Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.34 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HPN | P05981 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327962 | 0.85 | CA2 (0.39) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL24604233 | 0.80 | TTR (0.35) | HTTMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL23406091 | 0.79 | HNF4A (0.35) | CA2CA1 | |
| SCHEMBL21565069 | 0.78 | GABBR2 (0.36) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL9326808 | 0.77 | CYP1A2 (0.35) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL29740749 | 0.71 | ALDH1A1 (0.50) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL4464213 | 0.71 | ALDH1A1 (0.50) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL24053470 | 0.71 | ALOX15 (0.41) | SMN1; SMN2ALDH1A1TYRCYP1A2MAPT | |
| SCHEMBL11160785 | 0.71 | ALDH1A1 (0.54) | CA2CA1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL23450027 | 0.68 | TP53 (0.43) | CYP1A2MEN1KMT2AL3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11866393-B2 | 7,7′-dihalo-3,3,3′,3′-tetramethyl-1,1′-spirobiindane and preparation method thereof | ZHEJIANG UNIVERSITY (CN) | 2024-01-09 | — | — | US | disclosed |
| US-11530230-B2 | Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof | ZHEJIANG UNIVERSITY (CN) | 2022-12-20 | — | — | US | disclosed |
| US-20220213011-A1 | 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF | ZHEJIANG UNIVERSITY (CN) | 2022-07-07 | — | — | US | disclosed |
| US-20210163514-A1 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF | ZHEJIANG UNIVERSITY (CN) | 2021-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213011-A1 | 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF | TALDO1, REN, PKD1 | CA2 4450/4885CA1 4395/4885SMN1; SMN2 4121/4885 |
| US-11530230-B2 | Compound of 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand, and preparation method thereof | ORMDL3, TALDO1, TAC3 | CA2 3801/4885CA1 3668/4885SMN1; SMN2 4078/4885 |
| US-11866393-B2 | 7,7′-dihalo-3,3,3′,3′-tetramethyl-1,1′-spirobiindane and preparation method thereof | TALDO1, REN, PKD1 | CA2 4491/4885CA1 4438/4885SMN1; SMN2 4120/4885 |
| US-20210163514-A1 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF | ORMDL3, TALDO1, TAC3 | CA2 3705/4885CA1 3597/4885SMN1; SMN2 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.