Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiobarbituric SCHEMBL31059040 | 0.97 | GSK3A (0.38) | GSK3AGSK3BCRBNMAPTITGB3 | |
| Thiobarbituric SCHEMBL16027 | 0.97 | — | — | |
| Thiobarbituric SCHEMBL2351184 | 0.94 | GSK3A (0.36) | GSK3AGSK3BCRBNMAPTITGB3 | |
| Thiobarbituric SCHEMBL8216351 | 0.94 | GSK3A (0.36) | GSK3AGSK3BCRBNMAPTITGB3 | |
| Barbituric Acid SCHEMBL4726594 | 0.88 | ALDH1A1 (0.44) | GSK3AGSK3BCRBNMAPTITGB3 | |
| Thiobarbituric SCHEMBL144675 | 0.84 | ITGB3 (0.33) | GSK3AGSK3BMAPTITGB3ITGB1 | |
| Thiobarbituric SCHEMBL7714190 | 0.84 | ALDH1A1 (0.42) | GSK3AGSK3BMAPTALDH1A1CYP1A2 | |
| SCHEMBL8028070 | 0.82 | — | — | |
| Thiobarbituric SCHEMBL2455746 | 0.82 | ITGB3 (0.32) | GSK3AGSK3BITGB3ITGB1ITGAV | |
| Thiobarbituric SCHEMBL1867943 | 0.80 | ALDH1A1 (0.33) | GSK3AGSK3BITGB3ITGB1ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572597-B | Thiobarbituric acid-gold nanocluster and preparation method and application thereof | 青岛大学 | 2024-09-10 | — | — | CN | claimed |
| CN-115572597-A | Thiobabituric acid-gold nanocluster and preparation method and application thereof | 青岛大学 | 2023-01-06 | — | — | CN | claimed |
| US-8859769-B2 | Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine | ACTAVIS GROUP PTC EHF (IS) | 2014-10-14 | — | — | US | claimed |
| US-20130030176-A1 | PROCESSES FOR PREPARING TICAGRELOR INTERMEDIATE, 4,6-DICHLORO-5-NITRO-2-(PROPYLTHIO)PYRIMIDINE | ACTAVIS GROUP PTC EHF (IS) | 2013-01-31 | — | — | US | claimed |
| EP-2536695-A1 | IMPROVED PROCESSES FOR PREPARING TICAGRELOR INTERMEDIATE, 4,6-DICHLORO-5-NITRO-2-(PROPYLTHIO)PYRIMIDINE | Actavis Group Ptc Ehf (IS) | 2012-12-26 | — | — | EP | claimed |
| WO-2011101740-A1 | IMPROVED PROCESSES FOR PREPARING TICAGRELOR INTERMEDIATE, 4,6-DICHLORO-5-NITRO-2-(PROPYLTHIO)PYRIMIDINE | ACTAVIS GROUP PTC EHF (IS) | 2011-08-25 | — | — | WO | claimed |
| CN-121714568-A | Sophocarpine and application thereof in inhibiting formation of subretinal fibrosis | 上海优祺生物医药科技有限公司 | 2026-03-24 | — | — | CN | disclosed |
| CN-119948115-A | Azo dye, dye composition, colorant for anodic aluminum oxide, coloring method, and method for producing the dye | 保土谷化学工业株式会社 | 2025-05-06 | — | — | CN | disclosed |
| CN-115572597-B | Thiobarbituric acid-gold nanocluster and preparation method and application thereof | 青岛大学 | 2024-09-10 | — | — | CN | disclosed |
| WO-2024070669-A1 | AZO PIGMENT, DYE COMPOSITION, COLORANT AND COLORING METHOD FOR POSITIVE ELECTRODE ALUMINUM OXIDE, AND METHOD FOR PRODUCING AZO PIGMENT | 保土谷化学工業株式会社 | 2024-04-04 | — | — | WO | disclosed |
| CN-115572597-A | Thiobabituric acid-gold nanocluster and preparation method and application thereof | 青岛大学 | 2023-01-06 | — | — | CN | disclosed |
| US-8859769-B2 | Processes for preparing ticagrelor intermediate, 4,6-dichloro-5-nitro-2-(propylthio)pyrimidine | ACTAVIS GROUP PTC EHF (IS) | 2014-10-14 | — | — | US | disclosed |
| US-20130317220-A1 | NOVEL PROCESSES FOR PREPARING TRIAZOLO[4, 5-d]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2013-11-28 | — | — | US | disclosed |
| US-20130030176-A1 | PROCESSES FOR PREPARING TICAGRELOR INTERMEDIATE, 4,6-DICHLORO-5-NITRO-2-(PROPYLTHIO)PYRIMIDINE | ACTAVIS GROUP PTC EHF (IS) | 2013-01-31 | — | — | US | disclosed |
| EP-2536695-A1 | IMPROVED PROCESSES FOR PREPARING TICAGRELOR INTERMEDIATE, 4,6-DICHLORO-5-NITRO-2-(PROPYLTHIO)PYRIMIDINE | Actavis Group Ptc Ehf (IS) | 2012-12-26 | — | — | EP | disclosed |
| WO-2012085665-A2 | NOVEL PROCESSES FOR PREPARING TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF | ACTAVIS GROUP PATC EHF (IS) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011101740-A1 | IMPROVED PROCESSES FOR PREPARING TICAGRELOR INTERMEDIATE, 4,6-DICHLORO-5-NITRO-2-(PROPYLTHIO)PYRIMIDINE | ACTAVIS GROUP PTC EHF (IS) | 2011-08-25 | — | — | WO | disclosed |
| US-4942155-A | ANTIBIOTICS AND ANTITUMOR AGENTS | FARMITALIA CARLO ERBA S.P.A. (IT) | 1990-07-17 | — | — | US | disclosed |
| EP-0239774-B1 | NEW BIOSYNTHETIC ANTHRACYCLINES RELATED TO DAUNORUBICIN | FARMITALIA CARLO ERBA S.r.l. (IT) | 1989-06-21 | — | — | EP | disclosed |
| EP-0239774-A1 | New biosynthetic anthracyclines related to daunorubicin | FARMITALIA CARLO ERBA S.r.l. (IT) | 1987-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130317220-A1 | NOVEL PROCESSES FOR PREPARING TRIAZOLO[4, 5-d]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF | TBXAS1, TBXA2R, THPO | GSK3A 3217/4885GSK3B 3428/4885CRBN 3406/4885 |
| US-20130030176-A1 | PROCESSES FOR PREPARING TICAGRELOR INTERMEDIATE, 4,6-DICHLORO-5-NITRO-2-(PROPYLTHIO)PYRIMIDINE | THPO, NUDT1, DPYD | GSK3A 4526/4885GSK3B 4500/4885CRBN 3433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.