Thiobarbituric

Thiobarbituric

SCHEMBL1867943

O=C1CC(=O)NC(=S)N1.O=CCC=O

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
GSK3A P49840 1/20 0.33
GSK3B P49841 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ITGB3 P05106 1/20 0.31
ITGB1 P05556 1/20 0.31
ITGAV P06756 1/20 0.31
ITGA4 P13612 1/20 0.31
AHR P35869 1/20 0.30
PDK2 Q15119 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Thiobarbituric SCHEMBL31059040 0.83 GSK3A (0.38) ALDH1A1GSK3AGSK3BMEN1KMT2A
Thiobarbituric SCHEMBL16027 0.83
Thiobarbituric SCHEMBL8216351 0.80 GSK3A (0.36) ALDH1A1GSK3AGSK3BMEN1KMT2A
Thiobarbituric SCHEMBL2344775 0.80 GSK3A (0.36) ALDH1A1GSK3AGSK3BMEN1KMT2A
Thiobarbituric SCHEMBL2351184 0.80 GSK3A (0.36) ALDH1A1GSK3AGSK3BMEN1KMT2A
Thiobarbituric SCHEMBL7714190 0.76 ALDH1A1 (0.42) ALDH1A1GSK3AGSK3BMEN1KMT2A
Barbituric Acid SCHEMBL4726594 0.75 ALDH1A1 (0.44) ALDH1A1GSK3AGSK3BITGB3ITGB1
Thiobarbituric SCHEMBL144675 0.71 ITGB3 (0.33) ALDH1A1GSK3AGSK3BITGB3ITGB1
Biphenyl SCHEMBL5667075 0.71 TDP2 (0.49) ALDH1A1GSK3AGSK3BMEN1KMT2A
SCHEMBL8028070 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4244234-A1 POLYPEPTIDES AND METHODS FOR IMPROVING SKIN CONDITIONS InterK Peptide Therapeutics Limited (AU) 2023-09-20 EP disclosed
US-20220409510-A1 Polypeptides And Methods For Improving Skin Conditions INTERK PEPTIDE THERAPEUTICS LIMITED (AU) 2022-12-29 US disclosed
WO-2022099364-A1 POLYPEPTIDES AND METHODS FOR IMPROVING SKIN CONDITIONS INTERK PEPTIDE THERAPEUTICS LIMITED (AU) 2022-05-19 WO disclosed
EP-3938374-A2 PHENYLPROPANOID SACCHARIDE ESTERS, METHODS AND USES THEREOF UNIVERSIDADE NOVA DE LISBOA (PT) 2022-01-19 EP disclosed
US-20210380639-A1 Activating Agents INTERK PEPTIDE THERAPEUTICS LIMITED (AU) 2021-12-09 US disclosed
CN-111592405-B Organic water-soluble fertilizer capable of resisting wheat dry hot air and powdery mildew as well as preparation and application thereof 山东省农业科学院农业资源与环境研究所 2021-11-09 CN disclosed
CN-113166205-A Polypeptides and methods for improving skin conditions 英特肽治疗有限公司 2021-07-23 CN disclosed
EP-3794015-A1 ACTIVATING AGENTS InterK Peptide Therapeutics Limited (AU) 2021-03-24 EP disclosed
CN-112368293-A Activating agent 英特肽治疗有限公司 2021-02-12 CN disclosed
WO-2020183442-A2 PHENYLPROPANOID SACCHARIDE ESTERS, METHODS AND USES THEREOF UNIVERSIDADE NOVA DE LISBOA (PT) 2020-09-17 WO disclosed
EP-2147673-A1 Modulation of prostaglandin/cyclooxygenase metabolic pathways Hunter-Fleming Limited (GB) 2010-01-27 EP disclosed
CN-101594861-A The adjusting of prostaglandin/cyclooxygenase metabolic pathways HUNTER FLEMING LTD (GB) 2009-12-02 CN disclosed
US-20090197811-A1 ORALLY ADMINISTERED PEPTIDES TO IMPROVE OR PREVENT HEPATIC FIBROSIS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2009-08-06 US disclosed
WO-2009012400-A2 ORALLY ADMINISTERED PEPTIDES TO IMPROVE OR PREVENT HEPATIC FIBROSIS UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2009-01-22 WO disclosed
CN-101208083-A Treatment with statin and Omega-3 fatty acids and a combination product thereof RELIANT PHARMACEUTICALS INC (US) 2008-06-25 CN disclosed
CN-101098690-A Omega-3 fatty acids and dyslipidemic agent for lipid therapy RELIANT PHARMACEUTICALS INC (US) 2008-01-02 CN disclosed
US-20060205826-A1 Method of using carotenoids in the prevention of cognitive decline and for other neuroprotection functions KEMIN FOODS, L.C. 2006-09-14 US disclosed
US-6906059-B2 Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances SOLVAY PHARMACEUTICALS (DE) 2005-06-14 US disclosed
US-20030040512-A1 Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances SOLVAY PHARMACEUTICALS (DE) 2003-02-27 US disclosed
US-20020065258-A1 Non-estrogenic estradiol derivative compounds with antioxidative activity DROESCHER PETER (DE) 2002-05-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020065258-A1 Non-estrogenic estradiol derivative compounds with antioxidative activity CYP19A1, HSD17B11, SULT2A1 ALDH1A1 292/4885GSK3A 1977/4885GSK3B 2060/4885
US-20030040512-A1 Pharmaceutical composition with protective action against oxidative/toxic substances, especially cardiotoxic substances TNNC1, MB, FABP3 ALDH1A1 151/4885GSK3A 2490/4885GSK3B 2732/4885
US-20210380639-A1 Activating Agents LCK, CD69, NFATC1 ALDH1A1 4293/4885GSK3A 554/4885GSK3B 771/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.