SCHEMBL2345862

SCHEMBL2345862

C=C(C)C(=O)Nc1ccc(C(=O)[O-])c(O)c1.[Na+]

nearest known ligand 0.49

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A known ✓ P04350 1/20 0.36
TUBB known ✓ P07437 1/20 0.36
TUBA3C known ✓ P0DPH7 1/20 0.36
TUBA1B known ✓ P68363 1/20 0.36
TUBA4A known ✓ P68366 1/20 0.36
TUBB4B known ✓ P68371 1/20 0.36
TUBB3 known ✓ Q13509 1/20 0.36
TUBB2A known ✓ Q13885 1/20 0.36
TUBB8 known ✓ Q3ZCM7 1/20 0.36
TUBA3E known ✓ Q6PEY2 1/20 0.36
TUBA1A known ✓ Q71U36 1/20 0.36
TUBA1C known ✓ Q9BQE3 1/20 0.36
TUBB6 known ✓ Q9BUF5 1/20 0.36
TUBB2B known ✓ Q9BVA1 1/20 0.36
TUBB1 known ✓ Q9H4B7 1/20 0.36
TDP1 Q9NUW8 3/20 0.49
SMN1; SMN2 Q16637 1/20 0.48
POLB P06746 4/20 0.47
RXFP1 Q9HBX9 1/20 0.46
KDM4E B2RXH2 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrylic Acid SCHEMBL2349998 0.93 TDP1 (0.43) TDP1SMN1; SMN2POLBRXFP1KDM4E
SCHEMBL344699 0.84 KMT2A (0.56) TDP1SMN1; SMN2POLBRXFP1KDM4E
SCHEMBL31280644 0.84 KMT2A (0.56) TDP1SMN1; SMN2POLBRXFP1KDM4E
SCHEMBL28549035 0.84 SMN1; SMN2 (0.66) TDP1SMN1; SMN2POLBKDM4EL3MBTL1
Acrylic Acid SCHEMBL4529072 0.84 KMT2A (0.47) TDP1SMN1; SMN2POLBRXFP1KDM4E
SCHEMBL2345864 0.83 KMT2A (0.55) TDP1SMN1; SMN2POLBRXFP1KDM4E
SCHEMBL2345867 0.83 KMT2A (0.55) TDP1SMN1; SMN2POLBRXFP1KDM4E
SCHEMBL11804738 0.81 SMN1; SMN2 (0.66) TDP1SMN1; SMN2POLBKDM4EL3MBTL1
SCHEMBL21050613 0.80 TDP1 (0.57) TDP1SMN1; SMN2POLBRXFP1KDM4E
SCHEMBL30853148 0.80 TDP1 (0.57) TDP1SMN1; SMN2POLBRXFP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8008430-B2 High molecular weight polymers containing pendant salicylic acid groups for clarifying bayer process liquors NALCO COMPANY (US) 2011-08-30 US disclosed
US-7560032-B2 High molecular weight polymers containing pendant salicylic acid groups for clarifying Bayer process liquors NALCO COMPANY (US) 2009-07-14 US disclosed
EP-1597301-B1 HIGH MOLECULAR WEIGHT POLYMERS CONTAINING PENDENT SALICYCLIC ACID GROUPS FOR CLARIFYING BAYER PROCESS LIQUORS NALCO CO (US) 2008-04-09 EP disclosed
US-20060276597-A1 High molecular weight polymers containing pendant salicylic acid groups for clarifying bayer process liquors ECOLAB USA INC. 2006-12-07 US disclosed
US-20060273040-A1 High molecular weight polymers containing pendant salicylic acid groups for clarifying Bayer process liquors ECOLAB USA INC. 2006-12-07 US disclosed
US-7138472-B2 High molecular weight polymers containing pendant salicylic acid groups for clarifying bayer process liquors NALCO COMPANY (US) 2006-11-21 US disclosed
EP-1597301-A4 HIGH MOLECULAR WEIGHT POLYMERS CONTAINING PENDENT SALICYCLIC ACID GROUPS FOR CLARIFYING BAYER PROCESS LIQUORS NALCO CO (US) 2006-05-17 EP disclosed
EP-1597301-A2 HIGH MOLECULAR WEIGHT POLYMERS CONTAINING PENDENT SALICYCLIC ACID GROUPS FOR CLARIFYING BAYER PROCESS LIQUORS Nalco Company (US) 2005-11-23 EP disclosed
WO-2004076510-A2 HIGH MOLECULAR WEIGHT POLYMERS CONTAINING PENDENT SALICYCLIC ACID GROUPS FOR CLARIFYING BAYER PROCESS LIQUORS NALCO COMPANY (US) 2004-09-10 WO disclosed
US-20040024156-A1 High molecular weight polymers containing pendant salicylic acid groups for clarifying bayer process liquors ECOLAB USA INC. 2004-02-05 US disclosed