Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 5/20 | 0.49 |
| ▸ | PER2 | O15055 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CRY1 | Q16526 | 4/20 | 0.42 |
| ▸ | CRY2 | Q49AN0 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23469568 | 0.86 | PER2 (0.44) | PER2ALDH1A1MAPTMAPK1GAA | |
| SCHEMBL8148630 | 0.84 | MAPT (0.54) | PER2ALDH1A1MAPTMAPK1GAA | |
| SCHEMBL8143242 | 0.80 | MAPT (0.52) | PER2ALDH1A1MAPTMAPK1GAA | |
| SCHEMBL9976718 | 0.78 | PSEN1 (0.53) | PER2ALDH1A1MAPTMAPK1GAA | |
| SCHEMBL23469588 | 0.78 | PGR (0.53) | — | |
| SCHEMBL12608672 | 0.77 | CNR2 (0.49) | ALDH1A1MAPTLMNAKDM4ECNR2 | |
| SCHEMBL19885203 | 0.73 | ALDH1A1 (0.48) | PER2ALDH1A1MAPTMAPK1GAA | |
| SCHEMBL8134208 | 0.73 | KDM4E (0.57) | MPOPER2ALDH1A1MAPTMAPK1 | |
| SCHEMBL9976729 | 0.72 | RORA (0.51) | PER2ALDH1A1MAPTMAPK1GAA | |
| SCHEMBL31609292 | 0.72 | PER2 (0.48) | PER2ALDH1A1MAPTMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3939971-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | Synchronicity Pharma, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| EP-3129366-B1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | SYNCHRONICITY PHARMA INC (US) | 2021-06-09 | — | — | EP | disclosed |