Sugi Predict

Sugi Predict / Compounds / SCHEMBL2348709

SCHEMBL2348709

SCHEMBL2348709

NCc1cccnc1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 3/20 0.42
▸ LOXL2 Q9Y4K0 4/20 0.39
▸ CD38 P28907 1/20 0.38
▸ LOX P28300 1/20 0.38
▸ HTT P42858 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ MAOB P27338 1/20 0.35
▸ HDAC6 Q9UBN7 1/20 0.35
▸ TRPC5 Q9UL62 1/20 0.34
▸ PNMT P11086 2/20 0.34
▸ ADRB2 P07550 1/20 0.34
▸ RBP4 P02753 1/20 0.34
▸ GRM2 Q14416 1/20 0.33
▸ IDO1 P14902 1/20 0.32
▸ PTPN11 Q06124 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29392684 1.00 DPP4 (0.42) DPP4LOXL2CD38LOXHTT
Hydrochloric Acid SCHEMBL17292826 0.98 DPP4 (0.41) DPP4LOXL2CD38LOXHTT
SCHEMBL28051170 0.82 CD38 (0.36) CD38HTTHSD17B10HDAC6TRPC5
SCHEMBL30612302 0.80 KDM4E (0.42) CD38HTTHSD17B10HDAC6TRPC5
SCHEMBL843961 0.80 CD38 (0.36) CD38HTTHSD17B10HDAC6TRPC5
SCHEMBL738750 0.80 TRPC5 (0.37) DPP4CD38HTTHSD17B10HDAC6
SCHEMBL28965588 0.80 DPP4 (0.42) DPP4LOXL2PNMTADRB2
SCHEMBL12818788 0.80 CD38 (0.41) CD38HTTHSD17B10HDAC6TRPC5
SCHEMBL844943 0.80 KDM4E (0.42) CD38HTTHSD17B10HDAC6TRPC5
SCHEMBL13066846 0.80 CD38 (0.36) CD38HTTHSD17B10HDAC6TRPC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12606541-B2 PPARg modulators and methods of use EISAI R&D MANAGEMENT CO., LTD. (JP) 2026-04-21 — — US disclosed
CN-117247331-A Dibenzylbutane type lignan analogue and application thereof 中国人民解放军海军军医大学 2023-12-19 — — CN disclosed
US-20230348460-A1 ANTI-WOLBACHIA PYRIDO[2,3-d]PYRIMIDINECOMPOUNDS THE UNIVERSITY OF LIVERPOOL (GB) 2023-11-02 — — US disclosed
EP-4240736-A1 PPAR GAMMA MODULATORS AND METHODS OF USE Eisai R&D Management Co., Ltd. (JP) 2023-09-13 — — EP disclosed
CN-116635380-A PPARgamma modulators and methods of use 卫材R&D管理有限公司 2023-08-22 — — CN disclosed
EP-4219501-A1 COMPOUND CONTAINING 2,4-THIAZOLE RING, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF Shandong University (CN) 2023-08-02 — — EP disclosed
CN-111556871-B 1H-pyrazolo [4,3-b ] pyridines as PDE1 inhibitors H.隆德贝克有限公司 2023-07-07 — — CN disclosed
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE EISAI R&D MANAGEMENT CO., LTD. (JP) 2023-03-02 — — US disclosed
WO-2022246907-A1 COMPOUND CONTAINING 2,4-THIAZOLE RING, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 山东大学 2022-12-01 — — WO disclosed
CN-111465410-B Combination therapy comprising administration of 1H-pyrazolo [4,3-B ] pyridine H.隆德贝克有限公司 2022-10-25 — — CN disclosed
US-20150344429-A1 PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2015-12-03 — — US disclosed
EP-2473486-B1 PYRIMIDINES AS HEPCIDINE ANTAGONISTS VIFOR INT AG (CH) 2015-10-28 — — EP disclosed
US-20120202806-A1 Novel Pyrimidine- And Triazine-Hepcidine Antagonists VIFOR (INTERNATIONAL) AG (CH) 2012-08-09 — — US disclosed
US-20110230467-A1 4,6-DIAMINONICOTINAMIDE COMPOUND ASTELLAS PHARMA INC. (JP) 2011-09-22 — — US disclosed
US-20110230467-A1 4,6-DIAMINONICOTINAMIDE COMPOUND ASTELLAS PHARMA INC. (JP) 2011-09-22 — — US disclosed
US-20110230467-A1 4,6-DIAMINONICOTINAMIDE COMPOUND ASTELLAS PHARMA INC. (JP) 2011-09-22 — — US disclosed
EP-2361902-A1 4,6-DIAMINONICOTINAMIDE COMPOUND Astellas Pharma Inc. (JP) 2011-08-31 — — EP disclosed
US-7601714-B2 Pyrimidine derivatives useful as inhibitors of PKC-theta BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2009-10-13 — — US disclosed
US-20080287410-A1 PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA BARBOSA ANTONIO J M 2008-11-20 — — US disclosed
US-20060025433-A1 Pyrimidine derivatives useful as inhibitors of PKC-theta BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2006-02-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080287410-A1 PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA PRKCZ, PRKCQ, PRKCH DPP4 1876/4885LOXL2 3739/4885CD38 607/4885
US-20110230467-A1 4,6-DIAMINONICOTINAMIDE COMPOUND JAK3, JAK2, JAK1 DPP4 121/4885LOXL2 4607/4885CD38 1118/4885
US-20230348460-A1 ANTI-WOLBACHIA PYRIDO[2,3-d]PYRIMIDINECOMPOUNDS PWWP2B, WARS1, PNPO DPP4 2061/4885LOXL2 1547/4885CD38 3007/4885
US-20150344429-A1 PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS CNR2, CNR1, GPR52 DPP4 3956/4885LOXL2 2635/4885CD38 319/4885
US-20120202806-A1 Novel Pyrimidine- And Triazine-Hepcidine Antagonists HAMP, DHPS, SLC40A1 DPP4 2013/4885LOXL2 3583/4885CD38 414/4885
US-20060025433-A1 Pyrimidine derivatives useful as inhibitors of PKC-theta PRKCZ, PRKCQ, PRKCH DPP4 1876/4885LOXL2 3739/4885CD38 607/4885
US-20230062861-A1 PPARg MODULATORS AND METHODS OF USE PPARG, PPARA, PPARD DPP4 946/4885LOXL2 3780/4885CD38 3028/4885
US-12606541-B2 PPARg modulators and methods of use PPARG, PPARA, PPARD DPP4 2198/4885LOXL2 2527/4885CD38 2397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.