Sugi Predict

Sugi Predict / Compounds / SCHEMBL23532166

SCHEMBL23532166

SCHEMBL23532166

Cc1c(CO)oc2cccc(Br)c12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TTR P02766 4/20 0.42
▸ ALOX5 P09917 1/20 0.39
▸ MAPT P10636 2/20 0.33
▸ NPC1 O15118 2/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ KDM1A O60341 1/20 0.32
▸ CYP2C19 P33261 4/20 0.32
▸ ALDH1A1 P00352 2/20 0.32
▸ CYP2C9 P11712 2/20 0.32
▸ HSD17B10 Q99714 2/20 0.32
▸ EYA2 O00167 1/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ ABCC4 O15439 1/20 0.32
▸ PLIN1 O60240 1/20 0.32
▸ NR1I2 O75469 1/20 0.32
▸ USP2 O75604 1/20 0.32
▸ ABCB11 O95342 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ ALB P02768 1/20 0.32
▸ ESR1 P03372 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10744144 0.80 ALOX5 (0.57) ALOX5MAPTNPC1RAB9AKDM1A
SCHEMBL23532030 0.79 ALOX5 (0.38) TTRALOX5MAPTNPC1RAB9A
SCHEMBL28851548 0.79 TTR (0.37) TTRALOX5MAPTALDH1A1MEN1
SCHEMBL8081887 0.74 LOXL2 (0.39) ALOX5NPC1RAB9AALDH1A1MEN1
SCHEMBL3606887 0.73 MMP2 (0.44) ALOX5MAPTCYP2C19ALDH1A1MEN1
SCHEMBL6872423 0.72 NMT2 (0.42) ADRB1EDNRA
SCHEMBL2256874 0.72 KDM4E (0.46) MAPTNPC1RAB9ACYP2C19ALDH1A1
SCHEMBL29241045 0.70 MAOA (0.33) TTRKDM1AALDH1A1MAOA
SCHEMBL3613401 0.70 MMP2 (0.38) —
SCHEMBL23532015 0.70 EDNRA (0.62) TTRMAPTNPC1RAB9AKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12473283-B2 Compounds and their use DEBIOPHARM INTERNATIONAL S.A. (CH) 2025-11-18 — — US disclosed
CN-115151541-B Novel compounds and uses thereof 德彪药业国际股份公司 2024-06-25 — — CN disclosed
US-20230159519-A1 NOVEL COMPOUNDS AND THEIR USE DEBIOPHARM INTERNATIONAL S.A. (CH) 2023-05-25 — — US disclosed
US-20230159519-A1 NOVEL COMPOUNDS AND THEIR USE DEBIOPHARM INTERNATIONAL S.A. (CH) 2023-05-25 — — US disclosed
US-20230159519-A1 NOVEL COMPOUNDS AND THEIR USE DEBIOPHARM INTERNATIONAL S.A. (CH) 2023-05-25 — — US disclosed
EP-4077324-A1 NOVEL COMPOUNDS AND THEIR USE Debiopharm International SA (CH) 2022-10-26 — — EP disclosed
CN-115151541-A Novel compound and use thereof 德彪药业国际股份公司 2022-10-04 — — CN disclosed
WO-2021123372-A1 NOVEL COMPOUNDS AND THEIR USE DEBIOPHARM INTERNATIONAL S.A. (CH) 2021-06-24 — — WO disclosed
WO-2021123372-A1 NOVEL COMPOUNDS AND THEIR USE DEBIOPHARM INTERNATIONAL S.A. (CH) 2021-06-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159519-A1 NOVEL COMPOUNDS AND THEIR USE LSS, PGLS, LDHB TTR 4419/4885ALOX5 3357/4885MAPT 1933/4885
US-12473283-B2 Compounds and their use LSS, PGLS, LDHB TTR 4070/4885ALOX5 3284/4885MAPT 1798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.