Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.32 |
| ▸ | PTAFR | P25105 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536533 | 0.85 | HTR6 (0.40) | ENPP1HTR6KDM4ELMNAL3MBTL1 | |
| SCHEMBL23536635 | 0.78 | HSD17B10 (0.48) | HTR6KDM4ELMNAALDH1A1 | |
| SCHEMBL23536682 | 0.76 | HTR6 (0.34) | HTR6LMNAPTGDR2LOXL2CYP2D6 | |
| SCHEMBL23536839 | 0.74 | HSD17B10 (0.39) | JAK2JAK1HTR6LMNAALDH1A1 | |
| SCHEMBL23536550 | 0.73 | HTR6 (0.34) | HTR6LMNAALDH1A1LOXL2CYP2D6 | |
| SCHEMBL23536641 | 0.73 | HTT (0.46) | HTR6LMNAALDH1A1CYP2D6GBA1 | |
| SCHEMBL23536596 | 0.73 | SLC6A2 (0.39) | HTR6LMNAPTGDR2CYP2D6GBA1 | |
| SCHEMBL23536666 | 0.71 | GPR119 (0.34) | HTR6L3MBTL1ALDH1A1CYP2D6 | |
| SCHEMBL23536661 | 0.70 | SMN1; SMN2 (0.46) | HTR6LMNAPTGDR2CYP2D6GBA1 | |
| SCHEMBL23536713 | 0.69 | CYP2C19 (0.41) | HTR6KDM4ELMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |