Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536635 | 0.80 | HSD17B10 (0.48) | HSD17B10LMNAKMT2AMEN1RXFP1 | |
| SCHEMBL23536839 | 0.77 | HSD17B10 (0.39) | JAK2JAK1HSD17B10LMNAKMT2A | |
| SCHEMBL23536550 | 0.73 | HTR6 (0.34) | HSD17B10LMNAKMT2AMEN1TSHR | |
| SCHEMBL23536666 | 0.73 | GPR119 (0.34) | HSD17B10KMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23536682 | 0.70 | HTR6 (0.34) | LMNAKMT2AGAAMAPTLOXL2 | |
| SCHEMBL23536533 | 0.69 | HTR6 (0.40) | LMNAKMT2AMEN1L3MBTL1LOXL2 | |
| SCHEMBL23536713 | 0.69 | CYP2C19 (0.41) | LMNAKMT2AMEN1TSHRHTT | |
| SCHEMBL31713465 | 0.67 | KMT2A (0.42) | HSD17B10KMT2AMEN1RXFP1GAA | |
| SCHEMBL23536596 | 0.67 | SLC6A2 (0.39) | LMNAKMT2AMEN1GAATSHR | |
| SCHEMBL23536612 | 0.66 | JAK2 (0.35) | JAK2JAK1LMNAALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |