Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.30 |
| ▸ | FABP1 | P07148 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23536524 | 0.88 | SMN1; SMN2 (0.36) | LMNAGAATP53HTTSMN1; SMN2 | |
| SCHEMBL23536541 | 0.81 | RORC (0.37) | HSD11B1PDE4AMAPTHCRTR1RORC | |
| SCHEMBL23536663 | 0.79 | HTR6 (0.46) | LMNAGAATP53HTTSMN1; SMN2 | |
| SCHEMBL23536561 | 0.71 | RORC (0.36) | HSD11B1PDE4AHTR6MAPTHCRTR1 | |
| Formic Acid SCHEMBL23536757 | 0.71 | LMNA (0.33) | LMNAGAATP53HTTSMN1; SMN2 | |
| SCHEMBL23536619 | 0.70 | TP53 (0.34) | LMNAGAATP53HTTSMN1; SMN2 | |
| SCHEMBL23536667 | 0.70 | LMNA (0.34) | LMNAGAATP53HTTSMN1; SMN2 | |
| SCHEMBL23536699 | 0.69 | HTR6 (0.52) | HTR6 | |
| SCHEMBL23536585 | 0.69 | LMNA (0.34) | LMNAGAATP53HTTSMN1; SMN2 | |
| SCHEMBL29932037 | 0.66 | MCOLN2 (0.37) | LMNAGAAHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |