SCHEMBL2368433

SCHEMBL2368433

CC(C)(C)c1ccccc1OP(Cl)c1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.41
ATM Q13315 1/20 0.41
MAPT P10636 2/20 0.38
NPSR1 Q6W5P4 2/20 0.38
TP53 P04637 1/20 0.38
ALDH1A1 P00352 5/20 0.38
KDM4E B2RXH2 3/20 0.38
GAA P10253 1/20 0.38
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
HSD17B10 Q99714 1/20 0.36
NAMPT P43490 1/20 0.35
TSHR P16473 1/20 0.35
RBP4 P02753 3/20 0.34
NISCH Q9Y2I1 1/20 0.34
BCHE P06276 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2961614 0.88 MAPT (0.36) TDP1ATMMAPTNPSR1TP53
SCHEMBL2960192 0.82 APEX1 (0.40) TDP1MAPTNPSR1ALDH1A1KDM4E
SCHEMBL11496623 0.82 CA2 (0.36) TDP1ATMMAPTNPSR1TP53
SCHEMBL3418456 0.81 TDP1 (0.42) TDP1ATMMAPTNPSR1TP53
SCHEMBL28363499 0.81 TDP1 (0.42) TDP1ATMMAPTNPSR1TP53
SCHEMBL8751529 0.81 ALDH1A1 (0.45) TDP1ATMMAPTNPSR1TP53
SCHEMBL4593818 0.81 MAPT (0.42) TDP1ATMMAPTNPSR1TP53
SCHEMBL27772030 0.79 NAMPT (0.44) TDP1ATMMAPTNPSR1TP53
SCHEMBL2952176 0.77 ALDH1A1 (0.40) TDP1ALDH1A1KDM4EGAATSHR
SCHEMBL380498 0.77 MAPT (0.44) TDP1ATMMAPTNPSR1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1472201-B1 METHOD FOR THE SEPARATION OF ACIDS FROM CHEMICAL REACTION MIXTURES BY MEANS OF IONIC FLUIDS BASF SE (DE) 2014-08-13 EP disclosed
EP-2044092-B1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2011-09-28 EP disclosed
US-7851656-B2 Method for producing organic phosphorous compounds containing halogens BASF SE (DE) 2010-12-14 US disclosed
US-7851656-B2 Method for producing organic phosphorous compounds containing halogens BASF SE (DE) 2010-12-14 US disclosed
US-7851656-B2 Method for producing organic phosphorous compounds containing halogens BASF SE (DE) 2010-12-14 US disclosed
US-7767852-B2 Removal by salt formation BASF AKTIENGESELLSCHAFT (DE) 2010-08-03 US disclosed
US-20090281356-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2009-11-12 US disclosed
US-20090281356-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2009-11-12 US disclosed
US-20090281356-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2009-11-12 US disclosed
EP-2044092-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2009-04-08 EP disclosed
US-20080083606-A1 preparing aminodihalophosphines, diaminohalophosphines, triaminophosphines, phosphorous ester diamides, aminophosphines, diaminophosphines, phosphorous ester amide halides and aminophosphine halides with elimination of an acid in the presence of an auxiliary base BASF AKTIENGESELLSCHAFT (DE) 2008-04-10 US disclosed
US-7351339-B2 Using an auxiliary base to form a salt with the acid which is liquid at low enough temperature so that value product does not decompose during the removal of the liquid salt; e.g. acid catalyst removal; ionic liquids BASF AKTIENGESELLSCHAFT (DE) 2008-04-01 US disclosed
WO-2008006735-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2008-01-17 WO disclosed
WO-2008006735-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE BASF SE (DE) 2008-01-17 WO disclosed
EP-1470136-B1 METHOD FOR THE SEPARATION OF ACIDS FROM CHEMICAL REACTION MIXTURES BY MEANS OF IONIC FLUIDS BASF AG (DE) 2007-03-28 EP disclosed
US-20050020857-A1 Removal by salt formation BASF AKTIENGESELLSCHAFT (DE) 2005-01-27 US disclosed
EP-1472201-A2 METHOD FOR THE SEPARATION OF ACIDS FROM CHEMICAL REACTION MIXTURES BY MEANS OF IONIC FLUIDS BASF AKTIENGESELLSCHAFT (DE) 2004-11-03 EP disclosed
EP-1470136-A1 METHOD FOR THE SEPARATION OF ACIDS FROM CHEMICAL REACTION MIXTURES BY MEANS OF IONIC FLUIDS BASF AKTIENGESELLSCHAFT (DE) 2004-10-27 EP disclosed
WO-2003062171-A2 METHOD FOR THE SEPARATION OF ACIDS FROM CHEMICAL REACTION MIXTURES BY MEANS OF IONIC FLUIDS BASF AKTIENGESELLSCHAFT (DE) 2003-07-31 WO disclosed
WO-2003062251-A1 METHOD FOR THE SEPARATION OF ACIDS FROM CHEMICAL REACTION MIXTURES BY MEANS OF IONIC FLUIDS BASF AKTIENGESELLSCHAFT (DE) 2003-07-31 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090281356-A1 METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE PRXL2A, XRN2, POLR2B TDP1 1546/4885ATM 3382/4885MAPT 4384/4885
US-20050020857-A1 Removal by salt formation PHOSPHO1, AASDHPPT, INPP5B TDP1 1248/4885ATM 710/4885MAPT 3473/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.