Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442606 | 0.85 | HSD11B1 (0.40) | RBP4HSD11B1SLC6A7CA12CA1 | |
| SCHEMBL409942 | 0.85 | SLC6A7 (0.33) | SLC6A7KCNN4TP53MAPTAKT1 | |
| SCHEMBL2373555 | 0.79 | KCNN4 (0.34) | KCNN4SCN9AHTR2A | |
| SCHEMBL442604 | 0.78 | P2RX7 (0.31) | ELANEKDM4ECYP1A2CYP2C19TDP1 | |
| SCHEMBL2373398 | 0.74 | BRAF (0.36) | MAPTALDH1A1TSHR | |
| SCHEMBL12296240 | 0.74 | — | — | |
| SCHEMBL410925 | 0.74 | TACR1 (0.34) | TRPV1TP53MAPTKDM4ECYP1A2 | |
| SCHEMBL14920004 | 0.73 | — | — | |
| SCHEMBL442116 | 0.73 | MAPT (0.39) | RBP4HSD11B1SLC6A7TRPV1KCNN4 | |
| SCHEMBL12296769 | 0.72 | KCNN4 (0.34) | KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256950-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | CELGENE CORPORATION (US) | 2014-09-11 | — | — | US | disclosed |
| EP-2550280-B1 | PYRIDOTHIAZINES HAVING HERBICIDAL ACTION | BASF SE (DE) | 2014-02-26 | — | — | EP | disclosed |
| US-8440594-B2 | Pyridothiazines having herbicidal action | BASF SE (DE) | 2013-05-14 | — | — | US | disclosed |
| EP-2550280-A1 | PYRIDOTHIAZINES HAVING HERBICIDAL ACTION | BASF SE (DE) | 2013-01-30 | — | — | EP | disclosed |
| US-20130005575-A1 | Pyridothiazines Having Herbicidal Action | BASF SE (DE) | 2013-01-03 | — | — | US | disclosed |
| WO-2011117152-A1 | PYRIDOTHIAZINES HAVING HERBICIDAL ACTION | BASF SE (DE) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005575-A1 | Pyridothiazines Having Herbicidal Action | PNPO, PDXK, PLPBP | RBP4 3042/4885HSD11B1 1390/4885SLC6A7 841/4885 |
| US-20140256950-A1 | PROCESSES FOR THE PREPARATION OF 4-AMINO-2-(2,6-DIOXOPIPERIDIN-3-YL)ISOINDOLINE-1,3-DIONE COMPOUNDS | TNF, TRAF2, IL1A | RBP4 3761/4885HSD11B1 1504/4885SLC6A7 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.