Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.64 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.63 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 6/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14481173 | 0.87 | BCHE (0.53) | HRH3RAD52ACHEBCHE | |
| Hydrochloric Acid SCHEMBL31087706 | 0.78 | PABPC1 (0.97) | PABPC1EIF4HHRH3HRH2HRH1 | |
| SCHEMBL12300219 | 0.77 | TP53 (0.50) | PABPC1EIF4HHRH3 | |
| SCHEMBL2423836 | 0.76 | POLB (0.56) | PABPC1EIF4HHRH3 | |
| SCHEMBL12300220 | 0.75 | PABPC1 (0.71) | PABPC1EIF4HHRH3HRH2HRH1 | |
| Hydrochloric Acid SCHEMBL31087709 | 0.71 | RAD52 (1.00) | PABPC1EIF4HHRH3HRH2HRH1 | |
| SCHEMBL9736923 | 0.71 | PABPC1 (0.69) | PABPC1EIF4HHRH3HRH2HRH1 | |
| SCHEMBL9874867 | 0.70 | PABPC1 (0.71) | PABPC1EIF4HHRH3HRH2HRH1 | |
| SCHEMBL11838833 | 0.70 | ALDH1A1 (0.49) | — | |
| SCHEMBL8523409 | 0.70 | ACHE (0.81) | PABPC1EIF4HHRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552914-B1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2015-11-11 | — | — | EP | claimed |
| US-9029387-B2 | Benzonaphthyridinamines as autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2015-05-12 | — | — | US | claimed |
| US-20130012505-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-01-10 | — | — | US | claimed |
| EP-2552914-B1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2015-11-11 | — | — | EP | disclosed |
| US-9029387-B2 | Benzonaphthyridinamines as autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2015-05-12 | — | — | US | disclosed |
| EP-2552914-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2013-02-06 | — | — | EP | disclosed |
| US-20130012505-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-01-10 | — | — | US | disclosed |
| WO-2011116867-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2011-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012505-A1 | BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS | ENPP2, LYPLAL1, LYPLA1 | PABPC1 1295/4885EIF4H 4825/4885HRH3 496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.