Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17294190 | 0.98 | HSD17B10 (0.39) | TSHRHSD17B10LMNAALDH1A1MAPT | |
| SCHEMBL9393203 | 0.80 | PDE5A (0.35) | TSHRHSD17B10LMNAALDH1A1MEN1 | |
| SCHEMBL29598045 | 0.77 | TSHR (0.43) | TSHRHSD17B10LMNAALDH1A1MEN1 | |
| SCHEMBL29067975 | 0.77 | TSHR (0.43) | TSHRHSD17B10LMNAALDH1A1MEN1 | |
| SCHEMBL1012052 | 0.77 | TSHR (0.43) | TSHRHSD17B10LMNAALDH1A1MEN1 | |
| SCHEMBL29829226 | 0.76 | ALDH1A1 (0.37) | TSHRHSD17B10LMNAALDH1A1MAPT | |
| SCHEMBL6567872 | 0.74 | MEN1 (0.32) | TSHRHSD17B10LMNAALDH1A1MEN1 | |
| SCHEMBL11451580 | 0.73 | GAA (0.44) | TSHRHSD17B10LMNAALDH1A1MAPT | |
| SCHEMBL2672871 | 0.73 | PDE5A (0.45) | TSHRLMNAMEN1KMT2APDE5A | |
| SCHEMBL145905 | 0.72 | TSHR (0.46) | TSHRHSD17B10LMNAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6784224-B2 | STORAGE STABLE, GELATION INHIBITION, CONSISTS OF (METH)ACRYLATE MONOMERS, A FILLER AND A PYRIMIDINETRIONES CATALYST; MULTI-PASTES CONTAINS DIFFERENT COMPONENTS, MIXED WITH EACH OTHER TO POLYMERIZE; DENTAL ADHESIVES | GC CORPORATION (JP) | 2004-08-31 | — | — | US | claimed |
| US-9381140-B2 | Radically polymerisable dental material, cured product and usage | KETTENBACH GMBH & CO. KG (DE) | 2016-07-05 | — | — | US | disclosed |
| US-9114079-B2 | Polymerizable dental material comprising reactive paste formers, hardened dental material and use thereof | KETTENBACH GMBH & CO. KG (DE) | 2015-08-25 | — | — | US | disclosed |
| US-20150231041-A1 | Radically Polymerisable Dental Material, Cured Product and Usage | KETTENBACH GMBH & CO. KG (DE) | 2015-08-20 | — | — | US | disclosed |
| US-8791115-B2 | Combination of triazine derivatives and insulin sensitisers | POXEL SAS (FR) | 2014-07-29 | — | — | US | disclosed |
| US-20140050786-A1 | COMBINATION OF TRIAZINE DERIVATIVES AND INSULIN SENSITISERS | POXEL SAS (FR) | 2014-02-20 | — | — | US | disclosed |
| US-20130225699-A1 | Polymerizable Dental Material Comprising Reactive Paste Formers, Hardened Dental Material and Use Thereof | KETTENBACH GMBH & CO. KG (DE) | 2013-08-29 | — | — | US | disclosed |
| US-8012958-B2 | Modulate gene expression of gamma-aminobutyric acid receptors ; antidepressants; psychological disorders; obsessive compulsive disorders ; eating disorders | Hythlam, Inc. (US) | 2011-09-06 | — | — | US | disclosed |
| US-20100285117-A1 | COMBINATION OF TRIAZINE DERIVATIVES AND INSULIN SENSITISERS | POXEL SAS (FR) | 2010-11-11 | — | — | US | disclosed |
| US-7666977-B2 | Poly(carbonate-co-urea) copolymers and melt transesterification method of preparing these copolymers | SABIC INNOVATIVE PLASTICS IP B.V. (NL) | 2010-02-23 | — | — | US | disclosed |
| US-20080275206-A1 | POLY(CARBONATE-CO-UREA) COPOLYMERS AND MELT TRANSESTERIFICATION METHOD OF PREPARING THESE COPOLYMERS | GENERAL ELECTRIC COMPANY (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080255097-A1 | Methods for the Treatment of Substance Abuse and Dependence | HYTHIAM, INC. (US) | 2008-10-16 | — | — | US | disclosed |
| US-20080207601-A1 | Methods of and Compositions For the Prevention of Anxiety, Substance Abuse, and Dependence | HYTHIAM , INC. (US) | 2008-08-28 | — | — | US | disclosed |
| EP-1408060-B1 | Paste-like polymerizable composition | G C DENTAL IND CORP (JP) | 2007-12-12 | — | — | EP | disclosed |
| US-20070031779-A1 | Nozzle for dental composition | GC CORPORATION (JP) | 2007-02-08 | — | — | US | disclosed |
| EP-1749500-A1 | Nozzle for dental composition | GC Corporation (JP) | 2007-02-07 | — | — | EP | disclosed |
| US-6784224-B2 | STORAGE STABLE, GELATION INHIBITION, CONSISTS OF (METH)ACRYLATE MONOMERS, A FILLER AND A PYRIMIDINETRIONES CATALYST; MULTI-PASTES CONTAINS DIFFERENT COMPONENTS, MIXED WITH EACH OTHER TO POLYMERIZE; DENTAL ADHESIVES | GC CORPORATION (JP) | 2004-08-31 | — | — | US | disclosed |
| EP-1408060-A1 | Paste-like polymerizable composition | GC Corporation (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-20040068041-A1 | Paste-like polymerizable composition | GC CORPORATION (JP) | 2004-04-08 | — | — | US | disclosed |
| US-4382983-A | PARTIALLY HYDROLYZED SILOXANE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225699-A1 | Polymerizable Dental Material Comprising Reactive Paste Formers, Hardened Dental Material and Use Thereof | ME1, ME2, ME3 | TSHR 4358/4885HSD17B10 1139/4885LMNA 2522/4885 |
| US-20140050786-A1 | COMBINATION OF TRIAZINE DERIVATIVES AND INSULIN SENSITISERS | GPR119, INSR, IRS1 | TSHR 127/4885HSD17B10 1374/4885LMNA 4762/4885 |
| US-20100285117-A1 | COMBINATION OF TRIAZINE DERIVATIVES AND INSULIN SENSITISERS | GPR119, INSR, IRS1 | TSHR 127/4885HSD17B10 1374/4885LMNA 4762/4885 |
| US-20150231041-A1 | Radically Polymerisable Dental Material, Cured Product and Usage | MMAB, MTCL3, TUBB4B | TSHR 2630/4885HSD17B10 2606/4885LMNA 2952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.