Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.42 |
| ▸ | HTR3B | O95264 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770450 | 0.90 | HTR3E (0.43) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770808 | 0.88 | HTR3E (0.38) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770731 | 0.88 | HTR3A (0.40) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770663 | 0.86 | CYP1A2 (0.43) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770819 | 0.85 | HTR3A (0.41) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770661 | 0.83 | HTR3A (0.39) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770669 | 0.83 | HTR3A (0.40) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL23770475 | 0.81 | L3MBTL1 (0.39) | ALDH1A1MEN1KMT2AMAPK14KDM4E | |
| SCHEMBL23770837 | 0.81 | SMO (0.34) | HTR3EHTR3BALDH1A1HTR3AHTR3D | |
| SCHEMBL19925768 | 0.79 | HTR3E (0.40) | HTR3EHTR3BALDH1A1HTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |