Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.41 |
| ▸ | HTR3B | O95264 | 2/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | BPTF | Q12830 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770650 | 0.91 | PTPN11 (0.32) | PTPN11 | |
| SCHEMBL23770731 | 0.91 | HTR3A (0.40) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL23770606 | 0.89 | ADRB2 (0.43) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL23770669 | 0.86 | HTR3A (0.40) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL23770862 | 0.85 | HTR3E (0.42) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL23770808 | 0.83 | HTR3E (0.38) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL23770499 | 0.82 | PTPN11 (0.36) | PTPN11 | |
| SCHEMBL23770450 | 0.81 | HTR3E (0.43) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL23770739 | 0.80 | CNR2 (0.38) | PTPN11ADRB2 | |
| SCHEMBL19968829 | 0.79 | PTPN11 (0.40) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |