Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 8/20 | 0.34 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770650 | 0.87 | PTPN11 (0.32) | L3MBTL1MAOBCNR2CNR1MAPK1 | |
| SCHEMBL23770871 | 0.84 | MEN1 (0.38) | CNR1MEN1KMT2AMAPK1 | |
| SCHEMBL23770837 | 0.83 | SMO (0.34) | L3MBTL1CNR2CNR1MEN1KMT2A | |
| SCHEMBL23770862 | 0.81 | HTR3E (0.42) | MEN1KMT2AMAPK1HTTKDM4E | |
| SCHEMBL23770669 | 0.80 | HTR3A (0.40) | ALDH1A1MAPK14 | |
| SCHEMBL23770409 | 0.79 | BACE1 (0.35) | CNR2CNR1KMT2AMAPK1KDM4E | |
| SCHEMBL23770819 | 0.79 | HTR3A (0.41) | ALDH1A1MAPK14 | |
| SCHEMBL23770731 | 0.77 | HTR3A (0.40) | ALDH1A1MAPK14 | |
| SCHEMBL23770724 | 0.76 | MAP4K1 (0.34) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL23770739 | 0.76 | CNR2 (0.38) | CNR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |